Nos3^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nos3^M2Btlr
• Name: nitric oxide synthase 3, endothelial cell; mutation 2, Bruce Beutler
• MGI ID: MGI:6284778
• Synonyms: Peter
• Gene: Nos3 Location: Chr5:24569808-24589472 bp, + strand Genetic Position: Chr5, 11.32 cM
• Alliance: Nos3^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 24,377,855 (v38) on chromosome 5, or base pair 13,037 in the GenBank genomic region NC_000071. The mutation corresponds to residue 1,998 in the mRNA sequence NM_008713 within exon 16 of 26 total exons. The mutation results in a cysteine to tyrosine substitution at position 660 (C660Y) in the NOS3 protein. (J:272392)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos3 Mutation: 56 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3796

References

• Original: J:272392 Turer E, et al., Mutagenetix entry for Peter. MGI Direct Data Submission. 2019
• All: 1 reference(s)