Il12b Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il12b
interleukin 12b
MGI:96540

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Il10^tm1Cgn/Il10^tm1Cgn Il12b^tm1Jm/Il12b^tm1Jm involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	abnormal T-helper 2 cell differentiation	J:111712
	increased interleukin-13 secretion	J:111712
Il12a^tm1Jm/Il12a^tm1Jm Il12b^tm1Jm/Il12b^tm1Jm B6.129S1-Il12a^tm1Jm Il12b^tm1Jm	impaired natural killer cell mediated cytotoxicity	J:125611
Il12b^tm1Jm/Il12b^tm1Jm Il18^tm1Aki/Il18^tm1Aki involves: 129P2/OlaHsd * 129S1/SvImJ	abnormal T-helper 1 physiology	J:46514
	decreased interferon-gamma secretion	J:46514
	impaired natural killer cell mediated cytotoxicity	J:46514
Il12b^tm1Jm/Il12b^tm1Jm Rag2^tm1Fwa/Rag2^tm1Fwa involves: 129S/SvEv * 129S1/Sv	abnormal chemokine secretion	J:140483
	abnormal interferon secretion	J:140483
	increased susceptibility to bacterial infection	J:140483
	lung inflammation	J:140483
Il12b^tm1Jm/Il12b^tm1Jm Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	normal digestive/alimentary phenotype	J:83280
Il12b^tm1Jm/Il12b^tm1Jm Tnf^tm2Gkl/Tnf⁺ involves: 129S/SvEv * 129S1/Sv * C57BL/6J	small intestinal inflammation	J:108572

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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