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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hesx1
homeobox gene expressed in ES cells
MGI:96071
56 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6 * SJL 		exencephaly J:135132
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal eye morphology J:135132
postnatal lethality, incomplete penetrance J:135132
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal eye morphology J:135132
anophthalmia J:135132
microphthalmia J:135132
normal mortality/aging J:135132
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6 * SJL 		exencephaly J:135132
Hesx1em1(IMPC)J/Hesx1em1(IMPC)J
C57BL/6NJ-Hesx1em1(IMPC)J/Mmjax 		abnormal facial morphology J:211773
abnormal head shape J:211773
anophthalmia J:211773
cleft palate J:211773
facial cleft J:211773
preweaning lethality, complete penetrance J:211773
Hesx1tm1(cre)Jpmb/Hesx1+
involves: 129S/SvEv 		microphthalmia J:181005
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
B6.129S-Hesx1tm1(cre)Jpmb 		abnormal eye development J:135132
abnormal telencephalon development J:135132
anophthalmia J:135132
microphthalmia J:135132
perinatal lethality, complete penetrance J:135132
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
involves: 129S/SvEv 		abnormal anterior eye segment morphology J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal anterior eye segment morphology J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Hesx1tm1Icar/Hesx1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal craniofacial morphology J:47920
abnormal eye morphology J:47920
abnormal forebrain morphology J:47920
abnormal nose morphology J:47920
Hesx1tm1Icar/Hesx1tm1Icar
involves: 129P2/OlaHsd 		abnormal forebrain development J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Hesx1tm1Icar/Hesx1tm1Icar
involves: 129P2/OlaHsd * C57BL/6 		abnormal craniofacial morphology J:47920
abnormal eye morphology J:47920
abnormal forebrain development J:47920
abnormal frontonasal prominence morphology J:142649
abnormal hypothalamus morphology J:47920
abnormal midbrain-hindbrain boundary development J:135132
abnormal nasal cavity morphology J:47920
abnormal nasal pit morphology J:47920
abnormal nasal placode morphology J:47920
abnormal olfactory epithelium morphology J:47920
abnormal optic cup morphology J:47920
abnormal optic vesicle formation J:47920
abnormal septum pellucidum morphology J:47920
abnormal telencephalon development J:47920
abnormal telencephalon morphology J:47920, J:135132
absent anterior commissure J:47920
absent corpus callosum J:47920
absent hippocampal commissure J:47920
absent otic vesicle J:47920
absent pituitary infundibular stalk J:47920
absent Rathke's pouch J:47920
anophthalmia J:47920, J:142649
bifurcated Rathke's pouch J:47920
decreased embryonic neuroepithelium thickness J:47920
decreased forebrain size J:47920, J:135132
enophthalmos J:47920
microcephaly J:47920
microphthalmia J:47920
neonatal lethality, incomplete penetrance J:47920
olfactory bulb hypoplasia J:47920
postnatal lethality, incomplete penetrance J:47920
short snout J:47920
small adenohypophysis J:47920
small embryonic telencephalon J:47920, J:142649
small vomeronasal organ J:47920
Hesx1tm1Icar/Hesx1tm2Jpmb
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N 		abnormal telencephalon development J:142649
anophthalmia J:142649
microphthalmia J:142649
Hesx1tm1Icar/Hesx1tm3Jpmb
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N 		abnormal forebrain development J:142649
abnormal forebrain morphology J:142649
Hesx1tm2Jpmb/Hesx1tm2Jpmb
involves: 129S/SvEv * C57BL/6J * FVB/N 		abnormal adenohypophysis morphology J:142649
abnormal craniofacial morphology J:142649
abnormal eye morphology J:142649
anophthalmia J:142649
ectopic pituitary gland J:142649
microphthalmia J:142649
Hesx1tm3Jpmb/Hesx1tm3Jpmb
involves: 129S/SvEv * C57BL/6J * FVB/N 		abnormal adenohypophysis morphology J:142649
abnormal anterior commissure morphology J:142649
abnormal corpus callosum morphology J:142649
abnormal dorsal telencephalic commissure morphology J:142649
abnormal forebrain morphology J:142649
abnormal frontonasal prominence morphology J:142649
abnormal pituitary gland morphology J:142649
abnormal Rathke's pouch development J:142649
abnormal telencephalon morphology J:142649
absent anterior commissure J:142649
absent frontonasal prominence J:142649
anophthalmia J:142649
decreased forebrain size J:142649
ectopic adenohypophysis J:142649
ectopic pituitary gland J:142649
microphthalmia J:142649
postnatal lethality, incomplete penetrance J:142649
small embryonic telencephalon J:142649
Hesx1tm4.1Jpmb/Hesx1tm4.1Jpmb
involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL 		abnormal forebrain development J:181005
anophthalmia J:181005
microphthalmia J:181005
small embryonic telencephalon J:181005
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory