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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hbb
hemoglobin beta chain complex
MGI:96020
109 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Not Specified 		abnormal erythrocyte morphology J:134980
abnormal kidney corticomedullary boundary morphology J:134980
abnormal Kupffer cell morphology J:134980
abnormal liver morphology J:134980
abnormal spleen white pulp morphology J:134980
anemia J:137709
anisocytosis J:134980
decreased erythrocyte cell number J:134980
decreased hematocrit J:134980
decreased hemoglobin content J:134980
decreased urine osmolality J:134980
enlarged spleen J:134980
extramedullary hematopoiesis J:134980
focal hepatic necrosis J:134980
increased liver iron level J:134980
increased spleen red pulp amount J:134980
kidney vascular congestion J:134980
liver vascular congestion J:134980
poikilocytosis J:134980
polychromatophilia J:134980
reticulocytosis J:134980
spleen vascular congestion J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4+
involves: 129 * BALB/c * C57BL/6J 		abnormal erythrocyte physiology J:227339
abnormal liver morphology J:227339
abnormal lung morphology J:227339
abnormal pulmonary circulation J:227339
abnormal renal tubule morphology J:227339
enlarged spleen J:227339
hepatic necrosis J:227339
increased mesangial cell number J:227339
liver inflammation J:227339
microcytic anemia J:227339
premature death J:227339
reticulocytosis J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J 		premature death J:227339
preweaning lethality, incomplete penetrance J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified 		anemia J:137709
normal hematopoietic system phenotype J:134980
normal liver/biliary system phenotype J:134980
normal renal/urinary system phenotype J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J 		microcytic anemia J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm2(HBG1,HBD,HBB*)Ryan
Not Specified 		abnormal proerythroblast morphology J:148521
anemia J:148521
anisopoikilocytosis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
extramedullary hematopoiesis J:148521
hemolytic anemia J:148521
increased circulating bilirubin level J:148521
intermingled spleen red and white pulp J:148521
low mean erythrocyte cell number J:148521
polychromatophilia J:148521
premature death J:148521
reticulocytosis J:148521
spherocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm3(HBG1,HBB)Tow
Not Specified 		abnormal definitive hematopoiesis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
high mean erythrocyte cell number J:148521
reticulocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm3(HBG1,HBB)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified 		anemia J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm4(HBB*)Tow/Hbbtm4(HBB*)Tow
Not Specified 		abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm5(HBG1,HBB*)Tow/Hbbtm5(HBG1,HBB*)Tow
Not Specified 		abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1Paz/Hba+
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal erythroid progenitor cell morphology J:204029
decreased erythroid progenitor cell number J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbb+
involves: 129S2/SvPas * 129S7/SvEvBrd 		normal hematopoietic system phenotype J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal embryonic erythrocyte morphology J:204029
abnormal embryonic erythropoiesis J:204029
abnormal erythroid progenitor cell morphology J:204029
decreased embryo size J:204029
decreased erythroid progenitor cell number J:204029
embryonic lethality during organogenesis, complete penetrance J:204029
liver hypoplasia J:204029
microcytic anemia J:204029
microcytosis J:204029
pallor J:204029
small liver J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/0
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * FVB/N 		abnormal penile erection J:135978
priapism J:135978
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/?
involves: 129S2/SvPas * 129S7/SvEvBrd * Black Swiss * C57BL/6 * DBA/2* FVB/N 		abnormal erythrocyte morphology J:44161
abnormal hemoglobin J:44161
abnormal kidney vasculature morphology J:44161
abnormal liver vasculature morphology J:44161
abnormal lung vasculature morphology J:44161
anemia J:44161
anisopoikilocytosis J:44161
decreased erythrocyte osmotic fragility J:44161
decreased hematocrit J:44161
decreased mean corpuscular hemoglobin J:44161
decreased mean corpuscular hemoglobin concentration J:44161
decreased mean corpuscular volume J:44161
hypoxia J:44161
increased heart weight J:44161
increased kidney iron level J:44161
increased kidney weight J:44161
increased liver iron level J:44161
increased spleen weight J:44161
kidney atrophy J:44161
kidney cyst J:44161
neonatal lethality, incomplete penetrance J:44161
renal fibrosis J:44161
reticulocytosis J:44161
spleen vascular congestion J:44161
Hbbd3th/Hbb+
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N * Swiss Webster 		abnormal erythrocyte morphology J:94190
abnormal urine homeostasis J:94190
anemia J:94190
decreased urine osmolality J:94190
increased circulating alanine transaminase level J:94190
increased circulating aspartate transaminase level J:94190
reticulocytosis J:94190
Hbbd3th/Hbb+
Tg(LCR-HBA1,LCR-HBB*)1Tow/0
involves: C57BL/6 * DBA/2J * SJL 		anemia J:127701
anisopoikilocytosis J:127701
decreased erythrocyte cell number J:127701
decreased hematocrit J:127701
decreased hemoglobin content J:127701
echinocytosis J:127701
enlarged spleen J:127701
reticulocytosis J:127701
Hbbd3th/Hbb+
Tg(LCR-HBA2,LCR-HBB*)1Cos/0
involves: C57BL/6J * CBA/J * DBA/2J 		abnormal erythrocyte morphology J:94193
abnormal gas homeostasis J:94193
abnormal hemoglobin J:94193
anemia J:94193
decreased hematocrit J:94193
decreased mean corpuscular volume J:94193
enlarged spleen J:94193
increased mean corpuscular hemoglobin concentration J:94193
increased susceptibility to induced morbidity/mortality J:94193
maternal effect J:94193
postnatal lethality, incomplete penetrance J:94193
reticulocytosis J:94193
Hbbd3th/Hbbd3th
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
involves: Swiss Webster 		abnormal erythrocyte morphology J:136653
abnormal mean corpuscular volume J:136653
normal hematopoietic system phenotype J:136653
reticulocytosis J:94190
Hbbd3th/Hbbd3th
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N * Swiss Webster 		abnormal brain morphology J:94190
abnormal erythrocyte morphology J:94190
abnormal hemoglobin J:94190
abnormal kidney afferent arteriole morphology J:94190
abnormal liver morphology J:94190
abnormal neuron morphology J:94190
abnormal spleen morphology J:94190
abnormal urine homeostasis J:94190
anemia J:94190
brain vascular congestion J:94190
decreased urine osmolality J:94190
enlarged kidney J:94190
enlarged liver J:94190
enlarged spleen J:94190
glomerular capillary congestion J:94190
increased circulating alanine transaminase level J:94190
increased circulating aspartate transaminase level J:94190
increased mean corpuscular hemoglobin J:94190
increased spleen red pulp amount J:94190
liver fibrosis J:94190
postnatal lethality J:94190
premature death J:94190
pulmonary alveolar hemorrhage J:94190
pulmonary interstitial fibrosis J:94190
pulmonary vascular congestion J:94190
renal fibrosis J:94190
reticulocytosis J:94190
spleen fibrosis J:94190
spleen vascular congestion J:94190
thick pulmonary interalveolar septum J:94190
Hbbd3th/Hbbd3th
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N 		abnormal erythrocyte morphology J:94190
increased mean corpuscular hemoglobin J:94190
reticulocytosis J:94190
Hbbtm1.1(HBG1,HBB*)Ryan/Hbb+
involves: C57BL/6J 		abnormal bone marrow cavity morphology J:147906
abnormal iron level J:147906
abnormal spleen morphology J:147906
anisopoikilocytosis J:147906
decreased erythrocyte cell number J:147906
decreased mean corpuscular hemoglobin J:147906
decreased mean corpuscular hemoglobin concentration J:147906
decreased mean corpuscular volume J:147906
enlarged spleen J:147906
extramedullary hematopoiesis J:147906
increased erythroid progenitor cell number J:147906
increased hemoglobin concentration distribution width J:147906
increased liver iron level J:147906
increased spleen iron level J:147906
increased spleen red pulp amount J:147906
intermingled spleen red and white pulp J:147906
microcytic anemia J:147906
reticulocytosis J:147906
Hbbtm1.1(HBG1,HBB*)Ryan/Hbbtm1.1(HBG1,HBB*)Ryan
involves: C57BL/6J 		perinatal lethality, complete penetrance J:147906
Hbbtm2Unc/Hbb+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal erythrocyte morphology J:64295
anisocytosis J:64295
decreased erythrocyte cell number J:64295
decreased hematocrit J:64295
decreased hemoglobin content J:64295
decreased mean corpuscular volume J:64295
enlarged spleen J:64295
extramedullary hematopoiesis J:64295
increased hemoglobin concentration distribution width J:64295
increased kidney iron level J:64295
increased liver iron level J:64295
increased mean corpuscular hemoglobin concentration J:64295
increased spleen iron level J:64295
poikilocytosis J:64295
Hbbtm2Unc/Hbbtm2Unc
involves: 129P2/OlaHsd * C57BL/6J 		decreased birth body size J:64295
pallor J:64295
postnatal lethality, complete penetrance J:64295
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory