86 phenotypes from 7 alleles in 23 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fmr1tm1.1Cidz/Fmr1tm1.1Cidz Tg(Pcp2-cre)2Mpin/0 involves: 129S1/Sv * 129X1/SvJ	abnormal eye blink conditioning behavior	J:101021
	abnormal long-term depression	J:101021
	abnormal Purkinje cell morphology	J:101021
Fmr1tm1.1Ics/Fmr1tm1.1Ics C57BL/6-Fmr1tm1.1Ics	abnormal excitatory synapse morphology	J:304982
	abnormal postsynaptic density morphology	J:304982
	abnormal response to novel object	J:304982
	abnormal response to social novelty	J:304982
	abnormal synaptic vesicle number	J:304982
	decreased vocalization	J:304982
	impaired synaptic plasticity	J:304982
	increased dendritic spine density	J:304982
	increased miniature excitatory postsynaptic current amplitude	J:304982
	reduced long-term potentiation	J:304982
Fmr1tm1.2Cidz/Y involves: 129P2/OlaHsd * 129/Sv * C57BL/6 * FVB/N	abnormal CNS synaptic transmission	J:176553
	abnormal hippocampus pyramidal cell morphology	J:176553
	abnormal miniature excitatory postsynaptic currents	J:176553
	enhanced long-term potentiation	J:176553
Fmr1tm1.2Cidz/Y involves: 129P2/OlaHsd * C57BL/6	enlarged testis	J:108008
Fmr1tm1Cgr/Y B6.129P2(FVB)-Fmr1tm1Cgr	normal behavior/neurological phenotype	J:151144
	decreased anxiety-related response	J:151144
	social withdrawal	J:151144
Fmr1tm1Cgr/Y B6.129P2-Fmr1tm1Cgr	abnormal circadian behavior	J:248316
	decreased locomotor activity	J:248316
	hyperactivity	J:248316
	hypodipsia	J:248316
	increased testis weight	J:119166, J:171292
Fmr1tm1Cgr/Y B6.129P2-Fmr1tm1Cgr/J	abnormal brain morphology	J:227667
	abnormal learning/memory/conditioning	J:102061
	abnormal spatial learning	J:227667
	abnormal startle reflex	J:102061
	increased locomotor activity	J:227667
	increased prepulse inhibition	J:102061
	increased stereotypic behavior	J:227667
Fmr1tm1Cgr/Y B6.129P2-Fmr1tm1Cgr/Nwu	abnormal locomotor activation	J:171069
	abnormal response to novelty	J:171069
	abnormal social investigation	J:171069
	normal behavior/neurological phenotype	J:171069
	decreased startle reflex	J:171069
	increased aggression towards mice	J:171069
	increased grooming behavior	J:171069
	increased prepulse inhibition	J:171069
Fmr1tm1Cgr/Y either: FVB.129P2(B6)-Fmr1tm1Cgr/J or FVB;129P2(B6)-Fmr1tm1Cgr/J	audiogenic seizures	J:85912
	decreased startle reflex	J:85912
	increased prepulse inhibition	J:85912
Fmr1tm1Cgr/Y FVB.129P2(B6)-Fmr1tm1Cgr/J	decreased startle reflex	J:113024
Fmr1tm1Cgr/Y FVB.129P2(B6)-Pde6b+ Fmr1tm1Cgr	abnormal associative learning	J:100197
	impaired cued conditioning behavior	J:100197
	reduced long-term potentiation	J:100197
	normal vision/eye phenotype	J:100197
Fmr1tm1Cgr/Y FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J	abnormal locomotor activation	J:171069
	abnormal response to novelty	J:171069
	abnormal social investigation	J:171069
	abnormal vocalization	J:171069
	decreased startle reflex	J:171069
	increased exploration in new environment	J:171069
	increased prepulse inhibition	J:171069
Fmr1tm1Cgr/Y involves: 129P2/OlaHsd	abnormal eye blink conditioning behavior	J:101021
	abnormal long-term depression	J:101021
	abnormal Purkinje cell morphology	J:101021
	abnormal spatial learning	J:34449
	enlarged testis	J:34449
	increased startle reflex	J:101021
	increased testis weight	J:34449
Fmr1tm1Cgr/Y involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal dendrite morphology	J:127792
	abnormal dendritic spine morphology	J:70399
	abnormal nerve fiber response	J:127792
	audiogenic seizures	J:127792
	impaired passive avoidance behavior	J:127792
	increased body weight	J:127792
	increased testis weight	J:127792
Fmr1tm1Cgr/Y involves: 129P2/OlaHsd * C57BL/6J	abnormal anxiety-related response	J:219363
	abnormal dendritic spine morphology	J:219363
	abnormal retina morphology	J:221083
	abnormal retina rod cell outer segment morphology	J:221083
	abnormal spatial learning	J:19220
	decreased a-wave amplitude	J:221083
	decreased b-wave amplitude	J:221083
	decreased startle reflex	J:219363
	enlarged testis	J:19220
	hyperactivity	J:219363
	increased exploration in new environment	J:19220
	increased locomotor activity	J:19220
	increased prepulse inhibition	J:219363
	increased testis weight	J:19220
	increased thermal nociceptive threshold	J:219363
Fmr1tm1Cgr/Y involves: 129P2/OlaHsd * FVB	abnormal hippocampal mossy fiber morphology	J:113177
	convulsive seizures	J:113177
	decreased anxiety-related response	J:151144
	impaired coordination	J:151144
	increased anxiety-related response	J:151144
	increased body weight	J:151144
	increased exploration in new environment	J:151144
	social withdrawal	J:151144
	tonic-clonic seizures	J:113177
	normal vision/eye phenotype	J:113177, J:151144
Fmr1tm1Cgr/Y involves: 129P2/OlaHsd * FVB/NJ	abnormal spatial learning	J:119166
	increased testis weight	J:119166
	normal vision/eye phenotype	J:119166
Fmr1tm1Cgr/Fmr1tm1Cgr B6.129P2-Fmr1tm1Cgr	abnormal object recognition memory	J:171292
	normal behavior/neurological phenotype	J:119166
	decreased aggression towards mice	J:171292
	hyperactivity	J:171292
	impaired conditioned place preference behavior	J:171292
	increased body weight	J:171292
	increased vertical activity	J:171292
Fmr1tm1Cgr/Fmr1tm1Cgr involves: 129P2/OlaHsd	abnormal dentate gyrus morphology	J:159211
	abnormal long-term depression	J:101021
	abnormal neuron differentiation	J:159211
	abnormal neuronal precursor proliferation	J:159211
	abnormal Purkinje cell morphology	J:101021
	increased startle reflex	J:101021
Fmr1tm1Cgr/Fmr1tm1Cgr involves: 129P2/OlaHsd * C57BL/6J	increased exploration in new environment	J:19220
	increased locomotor activity	J:19220
Fmr1tm1Rbd/Y B6.129-Fmr1tm1Rbd	abnormal long-term depression	J:155593
	audiogenic seizures	J:155593
	decreased anxiety-related response	J:155593
	decreased startle reflex	J:155593
	increased exploration in new environment	J:155593
	increased locomotor activity	J:155593
	increased stereotypic behavior	J:155593
	increased thermal nociceptive threshold	J:155593
Fmr1tm1Rbd/Y FVB.129-Fmr1tm1Rbd	increased testis weight	J:155593
Fmr1tm1Usdn/Y involves: 129S6/SvEvTac * C57BL/6	abnormal brain morphology	J:170720
	abnormal dendrite morphology	J:170720
	abnormal dendritic spine morphology	J:170720
	abnormal social investigation	J:170720
	decreased anxiety-related response	J:170720
	impaired passive avoidance behavior	J:170720
	increased locomotor activity	J:170720
	increased testis weight	J:170720
Fmr1tm1Usdn/Y involves: 129S6/SvEvTac * C57BL/6 * FVB	abnormal chromosome morphology	J:121413
	abnormal Purkinje cell morphology	J:121413
	decreased Purkinje cell number	J:121413
Fmr1tm1Usdn/Fmr1tm1Usdn B6.129S6(Cg)-Fmr1tm1Usdn	abnormal cumulus oophorus morphology	J:196840
	abnormal female germ cell morphology	J:196840
	abnormal female meiosis	J:196840
	abnormal granulosa cell morphology	J:196840
	abnormal ovarian follicle number	J:196840
	abnormal ovary morphology	J:196840
	abnormal tertiary ovarian follicle morphology	J:196840
	decreased corpora lutea number	J:196840
	increased atretic ovarian follicle number	J:196840
	ovary atrophy	J:196840
	ovary cyst	J:196840
	small ovary	J:196840
Fmr1tm2Cgr/Y involves: 129P2/OlaHsd	neuronal intranuclear inclusions	J:83170
Fmr1tm2Cgr/Y involves: 129P2/OlaHsd * C57BL/6J * FVB	abnormal behavior	J:104445
	abnormal learning/memory/conditioning	J:104445
	decreased grip strength	J:104445
	impaired coordination	J:104445