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Targeted Allele Detail
Symbol: Fmr1tm1.1Cidz
Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1.1, Chris I de Zeeuw
MGI ID: MGI:3603442
Synonyms: Fmr1 CKO, Fmr1cON, Fmr1loxP, Fmrp-cON
Gene: Fmr1  Location: ChrX:67722147-67761569 bp, + strand  Genetic Position: ChrX, 34.83 cM
Alliance: Fmr1tm1.1Cidz page
Germline Transmission:  Earliest citation of germline transmission: J:101021
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
Mutation detailsThe first coding exon was left flanked with loxP sites 2800 bp in front of exon 1 of the gene and and a second loxP site 260 bp after exon 1 in intron 1, upon removal of a floxed neomycin resistance cassette. This allele has some residual endogenous protein expression at either 1.5% or 10% nominal levels. (J:101021, J:108008, J:282335)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:  28 strains or lines available
Original:  J:101021 Koekkoek SK, et al., Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron. 2005 Aug 4;47(3):339-52
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory