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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mir21a
microRNA 21a
MGI:2676885
49 phenotypes from 9 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm1(CAG-Mir21)Jake/Gt(ROSA)26Sor+
Tg(Gfap-cre)#Mvs/0
involves: BALB/c * C57BL/6 * C57BL/6NHsd
abnormal astrocyte morphology J:192021
abnormal astrocyte physiology J:192021
abnormal response to injury J:192021
increased susceptibility to injury J:192021
Gt(ROSA)26Sortm1(tTA,tetO-Mir21)Fjsl/Gt(ROSA)26Sor+
Tg(Nes-cre)1Wmz/0
involves: C57BL/6 * C57BL/6J * SJL/J
abnormal bone marrow morphology J:163919
abnormal spleen morphology J:163919
abnormal thymus corticomedullary boundary morphology J:163919
abnormal thymus morphology J:163919
abnormal tumor morphology J:163919
anemia J:163919
decreased erythrocyte cell number J:163919
decreased hemoglobin content J:163919
decreased leukocyte cell number J:163919
enlarged lymph nodes J:163919
enlarged spleen J:163919
enlarged thymus J:163919
hindlimb paresis J:163919
hunched posture J:163919
increased lymphoma incidence J:163919
increased tumor incidence J:163919
intermingled spleen red and white pulp J:163919
premature death J:163919
respiratory distress J:163919
ruffled hair J:163919
Mir21atm1.1Eno/Mir21atm1.1Eno
involves: C57BL/6
normal cardiovascular system phenotype J:166911
increased heart weight J:166911
Mir21atm1.1Mer/Mir21atm1.1Mer
B6.129S1-Mir21atm1.1Mer
increased susceptibility to type IV hypersensitivity reaction J:179235
Mir21atm1.1Mer/Mir21atm1.1Mer
involves: 129S1/Sv * C57BL/6 * FVB/N
abnormal cytokine level J:179235
abnormal cytokine secretion J:179235
abnormal interferon level J:179235
abnormal interleukin level J:179235
decreased interleukin-4 secretion J:179235
increased interferon-gamma secretion J:179235
increased interleukin-12 secretion J:179235
increased susceptibility to type I hypersensitivity reaction J:179235
Mir21atm1.1Mtm/Mir21atm1.1Mtm
involves: 129P2/OlaHsd * C57BL/6 * FVB
normal mortality/aging J:181831
Mir21atm1.1Sho/Mir21atm1.1Sho
involves: 129 * C57BL/6
decreased susceptibility to kidney reperfusion injury J:183786
Mir21atm1.1Zqy/Mir21atm1.1Zqy
Tg(Tek-cre)12Flv/0
involves: 129S/SvEv * C3H * C57BL/6 * SJL
abnormal aorta collagen fibril morphology J:199907
abnormal blood vessel physiology J:199907
abnormal thoracic aorta morphology J:199907
decreased aorta elastin content J:199907
decreased mean systemic arterial blood pressure J:199907
decreased systemic arterial diastolic blood pressure J:199907
decreased vasodilation J:199907
Mir21atm1Yoli/Mir21atm1Yoli
involves: 129S6/SvEvTac * C57BL/6N
abnormal skin physiology J:173464
abnormal tumor pathology J:173464
decreased incidence of tumors by chemical induction J:173464
decreased physiological sensitivity to xenobiotic J:173464
Tg(CAG-Mir21,-EGFP)#Eno/0
involves: C3H * C57BL/6
normal neoplasm J:164198

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory