Mir21a^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Mir21a^tm1.1Eno
• Name: microRNA 21a; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:4881915
• Gene: Mir21a Location: Chr11:86474893-86474984 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Mir21a^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166911
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding sequence, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the coding sequence. Cre-mediated recombination removed the coding sequence and the neo cassette. (J:166911)

Expression

In Mice Carrying this Mutation:	52018 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir21a Mutation: 8 strains or lines available

References

• Original: J:164198 Hatley ME, et al., Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell. 2010 Sep 14;18(3):282-93
• All: 10 reference(s)