Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21atm1.1Eno mutation
(0 available);
any
Mir21a mutation
(8 available)
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cardiovascular system
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N |
• mice exhibit largely normal cardiac morphology and physiology, including response to stress
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• angiotensin II-treated mice exhibit a mildly exaggerated increased in heart weight compared with similarly treated wild-type mice
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growth/size/body
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• angiotensin II-treated mice exhibit a mildly exaggerated increased in heart weight compared with similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation
(2 available);
any
Kras mutation
(76 available)
Mir21atm1.1Eno mutation
(0 available);
any
Mir21a mutation
(8 available)
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neoplasm
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N |
• unlike Krastm3Tyj heterozygotes, mice do not develop skin papillomas or lung adenomcarcinomas
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• fewer than in Krastm3Tyj heterozygotes
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• mice exhibit decreased total tumor area relative to lung area compared with Krastm3Tyj heterozygotes
• however, tumor cell proliferation is the same as in Krastm3Tyj heterozygotes
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• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes
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• mice develop fewer thymic lymphoma, lung hyperplasia and lung adenomas than in Krastm3Tyj heterozygotes
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• fewer lung adenoma than in Krastm3Tyj heterozygotes
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respiratory system
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• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes
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• mice develop fewer lung hyperplasia than in Krastm3Tyj heterozygotes
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endocrine/exocrine glands
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• fewer than in Krastm3Tyj heterozygotes
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Analysis Tools