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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sik3
SIK family kinase 3
MGI:2446296
147 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sik3em1Iiis/Sik3+
involves: C57BL/6J 		abnormal sleep duration J:236598
Sik3Slp/Sik3+
involves: C57BL/6J * C57BL/6N 		abnormal brain wave pattern J:236598
abnormal circadian sleep/wake cycle J:236598
abnormal non-rapid eye movement sleep pattern J:236598
abnormal paradoxical sleep pattern J:236598
abnormal sleep duration J:236598
Sik3Slp/Sik3Slp
involves: C57BL/6J * C57BL/6N 		abnormal brain wave pattern J:236598
abnormal non-rapid eye movement sleep pattern J:236598
abnormal paradoxical sleep pattern J:236598
abnormal sleep duration J:236598
normal behavior/neurological phenotype J:236598
Sik3tm1.1Iiis/Sik3+
involves: C57BL/6N 		abnormal sleep duration J:236598
Sik3tm1a(EUCOMM)Hmgu/Sik3tm1a(EUCOMM)Hmgu
C57BL/6N-Sik3tm1a(EUCOMM)Hmgu/Wtsi 		abnormal bone structure J:211773
abnormal coat/hair pigmentation J:211773
abnormal cornea morphology J:211773
abnormal cranium morphology J:211773
abnormal femur morphology J:211773
abnormal fibula morphology J:211773
abnormal humerus morphology J:211773
abnormal joint morphology J:211773
abnormal pelvic girdle bone morphology J:211773
abnormal radius morphology J:211773
abnormal retina morphology J:211773
abnormal rib morphology J:211773
abnormal spine curvature J:211773
abnormal tail morphology J:211773
abnormal thoracic cage shape J:211773
abnormal tibia morphology J:211773
abnormal ulna morphology J:211773
abnormal vertebrae morphology J:211773
abnormal zygomatic bone morphology J:211773
decreased alpha-beta T cell number J:211773
decreased blood urea nitrogen level J:211773
decreased CD4-positive NK T cell number J:211773
decreased CD4-positive, alpha-beta T cell number J:211773
decreased CD5-positive gamma-delta T cell number J:211773
decreased circulating calcium level J:211773
decreased circulating cholesterol level J:211773
decreased circulating fructosamine level J:211773
decreased circulating glucose level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating potassium level J:211773
decreased early germinal center B cell number J:211773
decreased effector memory T-helper cell number J:211773
decreased erythrocyte cell number J:211773
decreased gamma-delta T cell number J:211773
decreased germinal center B cell number J:211773
decreased hematocrit J:211773
decreased KLRG1-positive NK cell number J:211773
decreased KLRG1-positive T-helper cell number J:211773
decreased Ly6C-positive mature NK cell number J:211773
decreased memory-marker CD4-negative NK T cell number J:211773
decreased memory-marker CD4-positive NK T cell number J:211773
decreased NK cell number J:211773
decreased NK T cell number J:211773
decreased regulatory T cell number J:211773
decreased T cell number J:211773
decreased T-helper cell number J:211773
decreased total body fat amount J:211773
female infertility J:211773
improved glucose tolerance J:211773
increased CD4-negative NK T cell number J:211773
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased CD8-positive, alpha-beta T cell number J:211773
increased CD8-positive, naive alpha-beta T cell number J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating amylase level J:211773
increased circulating bilirubin level J:211773
increased circulating sodium level J:211773
increased effector memory T-helper cell number J:211773
increased eosinophil cell number J:211773
increased follicular B cell number J:211773
increased granulocyte number J:211773
increased KLRG1+ CD8 alpha-beta T cell number J:211773
increased KLRG1-positive CD4-negative NK T cell number J:211773
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased KLRG1-positive T-helper cell number J:211773
increased lean body mass J:211773
increased Ly6C-positive NK T cell number J:211773
increased mean corpuscular hemoglobin J:211773
increased mean platelet volume J:211773
increased memory-marker gamma-delta T cell number J:211773
increased memory-marker NK cell number J:211773
increased NK cell number J:211773
increased plasmacytoid dendritic cell number J:211773
increased red blood cell distribution width J:211773
kyphosis J:211773
thrombocytopenia J:211773
Sik3tm1Htake/Sik3tm1Htake
involves: C57BL/6JJcl * C57BL/6N 		abnormal bile color J:183827
abnormal bile composition J:183827
abnormal cholesterol level J:183827
abnormal circulating hormone level J:183827
abnormal circulating protein level J:183827
abnormal eating behavior J:183827
abnormal energy homeostasis J:183827
abnormal fat cell differentiation J:183827
abnormal gallbladder epithelium morphology J:183827
abnormal gallbladder morphology J:183827
abnormal glucose homeostasis J:183827
abnormal hepatocyte morphology J:183827
abnormal homeostasis J:183827
abnormal lipid homeostasis J:183827
abnormal liver morphology J:183827
abnormal retinol level J:183827
cholestasis J:183827
decreased body weight J:183827
decreased brown adipose tissue amount J:183827
decreased circulating alanine transaminase level J:183827
decreased circulating cholesterol level J:183827
decreased circulating glucose level J:183827
decreased circulating HDL cholesterol level J:183827
decreased circulating insulin level J:183827
decreased circulating leptin level J:183827
decreased circulating triglyceride level J:183827
decreased circulating VLDL triglyceride level J:183827
decreased fat cell size J:183827
decreased gonadal fat pad weight J:183827
decreased kidney weight J:183827
decreased liver cholesterol level J:183827
decreased liver triglyceride level J:183827
decreased liver weight J:183827
decreased mesenteric fat pad weight J:183827
decreased pancreas weight J:183827
decreased renal fat pad weight J:183827
decreased subcutaneous adipose tissue amount J:183827
decreased susceptibility to diet-induced hepatic steatosis J:183827
decreased susceptibility to diet-induced obesity J:183827
enlarged gallbladder J:183827
improved glucose tolerance J:183827
increased adiponectin level J:183827
increased bile salt level J:183827
increased circulating alanine transaminase level J:183827
increased circulating alkaline phosphatase level J:183827
increased circulating bilirubin level J:183827
increased circulating triglyceride level J:183827
increased core body temperature J:183827
increased liver cholesterol level J:183827
increased oxygen consumption J:183827
increased respiratory quotient J:183827
intrahepatic cholestasis J:183827
neonatal lethality, incomplete penetrance J:183827
Sik3tm1Htake/Sik3tm1Htake
involves: C57BL/6N 		abnormal bone mineralization J:182752
abnormal bone structure J:182752
abnormal cartilage morphology J:182752
abnormal limb long bone morphology J:182752
abnormal parietal bone morphology J:182752
abnormal pelvic girdle bone morphology J:182752
abnormal vertebral column morphology J:182752
decreased body size J:182752
decreased body weight J:182752
decreased chondrocyte number J:182752
decreased length of long bones J:182752
decreased width of hypertrophic chondrocyte zone J:182752
delayed cranial suture closure J:182752
delayed intramembranous bone ossification J:182752
increased long bone epiphyseal plate size J:182752
large fontanelles J:182752
neonatal lethality, incomplete penetrance J:182752
rachitic rosary J:182752
rickets J:182752
scoliosis J:182752
short ribs J:182752
short sternum J:182752
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory