57 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Senp1em1(IMPC)H/Senp1em1(IMPC)H C57BL/6NTac-Senp1em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Senp1Gt(OST215108)Lex/Senp1+ B6;129S5-Senp1Gt(OST215108)Lex/Orl	enhanced coordination	J:82809
Senp1Gt(OST215108)Lex/Senp1Gt(OST215108)Lex B6;129S5-Senp1Gt(OST215108)Lex/Orl	prenatal lethality, complete penetrance	J:82809
Senp1Gt(XG001)Byg/Senp1Gt(XG001)Byg involves: 129P2/OlaHsd	abnormal erythropoiesis	J:141453
	anemia	J:141453
	decreased erythrocyte cell number	J:141453
	decreased erythroid progenitor cell number	J:141453
	decreased fetal size	J:141453
	normal hematopoietic system phenotype	J:141453
	lethality throughout fetal growth and development, incomplete penetrance	J:141453
	pallor	J:141453
	small liver	J:141453
Senp1m1Mku/Senp1m1Mku involves: 129	abnormal cell death	J:99175
	abnormal placental labyrinth vasculature morphology	J:99175
	lethality throughout fetal growth and development, complete penetrance	J:99175
	prenatal lethality	J:88845
Senp1tm1.1Eyeh/Senp1+ Tg(Pdx1-cre)6Tuv/0 involves: C57BL/6	impaired glucose tolerance	J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh Not Specified	abnormal pancreatic beta cell physiology	J:226392
	decreased insulin secretion	J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh Tg(Pdx1-cre)6Tuv/0 involves: C57BL/6	abnormal pancreatic beta cell physiology	J:226392
	decreased circulating insulin level	J:226392
	decreased insulin secretion	J:226392
	normal growth/size/body region phenotype	J:226392
	impaired ability to fire action potentials	J:226392
	impaired glucose tolerance	J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh Tg(Pdx1-cre/Esr1*)#Dam/0 involves: C57BL/6	decreased insulin secretion	J:226392
	impaired glucose tolerance	J:226392
Senp1tm1.1Wami/Senp1tm1.1Wami involves: 129 * C57BL/6	abnormal erythropoiesis	J:163428
	abnormal granulocyte differentiation	J:163428
	abnormal hemoglobin content	J:163428
	abnormal liver physiology	J:163428
	abnormal megakaryocyte progenitor cell morphology	J:163428
	abnormal monocyte differentiation	J:163428
	abnormal vascular development	J:163428
	abnormal vitelline vasculature morphology	J:163428
	anemia	J:163428
	decreased erythroid progenitor cell number	J:163428
	decreased liver weight	J:163428
	lethality throughout fetal growth and development, complete penetrance	J:163428
	pale liver	J:163428
	postnatal lethality, complete penetrance	J:163428
	prenatal lethality, complete penetrance	J:150995
	small liver	J:163428
Senp1tm1Wami/Senp1tm1Wami Tg(Adipoq-cre)1Evdr/0 B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr	abnormal pancreatic islet morphology	J:228009
	decreased body weight	J:228009
	decreased insulin secretion	J:228009
	normal homeostasis/metabolism phenotype	J:228009
	hyperglycemia	J:228009
	increased pancreatic beta cell apoptosis	J:228009
Senp1tm1Wami/Senp1tm1Wami Tg(Cdh5-cre)7Mlia/0 involves: 129 * C57BL/6 * FVB/N	normal homeostasis/metabolism phenotype	J:228009
Senp1tm1Wami/Senp1tm1Wami Tg(Fabp4-cre)#Abel/0 B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel	abnormal chemokine level	J:228009
	abnormal circulating cytokine level	J:228009
	abnormal cytokine level	J:228009
	abnormal fat cell morphology	J:228009
	abnormal pancreatic islet morphology	J:228009
	decreased body weight	J:228009
	decreased circulating cholesterol level	J:228009
	decreased circulating insulin level	J:228009
	decreased circulating triglyceride level	J:228009
	decreased fat cell size	J:228009
	decreased insulin secretion	J:228009
	decreased total fat pad weight	J:228009
	hyperglycemia	J:228009
	impaired glucose tolerance	J:228009
	increased anti-insulin autoantibody level	J:228009
	increased circulating C-reactive protein level	J:228009
	increased circulating interleukin-1 beta level	J:228009
	increased circulating interleukin-6 level	J:228009
	increased circulating ketone body level	J:228009
	increased circulating tumor necrosis factor level	J:228009
	increased fluid intake	J:228009
	increased susceptibility to autoimmune diabetes	J:228009
	insulin resistance	J:228009
	myocarditis	J:228009
	pancreas inflammation	J:228009
Senp1tm1Wami/Senp1tm1Wami Tg(Pdgfra-cre)1Clc/0 B6.Cg-Senp1tm1Wami Tg(Pdgfra-cre)1Clc	abnormal pancreatic beta cell physiology	J:228009
	abnormal pancreatic islet cell apoptosis	J:228009
	abnormal pancreatic islet morphology	J:228009
	decreased body weight	J:228009
	hyperglycemia	J:228009
Senp1tm1Wami/Senp1tm1Wami Tg(Tagln-cre)1Jjl/0 involves: 129 * C57BL/6 * FVB/N	normal homeostasis/metabolism phenotype	J:228009