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Tg(Pdx1-cre/Esr1*)#Dam
Transgene Detail
Summary
Symbol: Tg(Pdx1-cre/Esr1*)#Dam
Name: transgene insertion, Douglas A Melton
MGI ID: MGI:5008261
Synonyms: Pdx1-CreER
Transgene: Tg(Pdx1-cre/Esr1*)#Dam  Location: unknown  
Alliance: Tg(Pdx1-cre/Esr1*)#Dam page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Pdx1-cre/Esr1*)#Dam expression driven by 1 gene
 
Mutation detailsThe sequence encoding a tamoxifen-inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to the Ipf1 promoter to drive mosaic expression of cre recombinase in endocrine, exocrine, and duct tissue of the pancreas. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:76095)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdx1 (species not specified)
Summary of all recombinase alleles driven by Pdx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(Pdx1-cre/Esr1*)#Dam
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:172243 Porat S, et al., Control of pancreatic beta cell regeneration by glucose metabolism. Cell Metab. 2011 Apr 6;13(4):440-9
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory