Analysis Tools
homeostasis/metabolism
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• severe in tamoxifen-treated mice without beta-cell apoptosis
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Allele Symbol Allele Name Allele ID |
Tg(Pdx1-cre/Esr1*)#Dam transgene insertion, Douglas A Melton MGI:5008261 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe in tamoxifen-treated mice without beta-cell apoptosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• beta cells from tamoxifen-treated mice exhibit signs of DNA damage and apoptosis compared to control mice but to a lesser extent than in mice lacking Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas
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• severe in tamoxifen-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming
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• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in vitro, islets isolated from tamoxifen-treated male mice exhibit an impaired glucose and KCl-induced insulin secretory response in a perifusion assay, also shown as a reduced area under the curve (AUC) of the responses to glucose and KCl
• however, the insulin content of mutant islets is unchanged
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• tamoxifen-treated male mice exhibit an exaggerated glucose excursion in response to an oral glucose challenge
• however, insulin tolerance is similar to that in control littermates
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• in vitro, islets isolated from tamoxifen-treated male mice exhibit an impaired glucose and KCl-induced insulin secretory response in a perifusion assay, also shown as a reduced area under the curve (AUC) of the responses to glucose and KCl
• however, the insulin content of mutant islets is unchanged
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced immature beta cells at E17.5 in tamoxifen-treated mice
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• at E17.5 in tamoxifen-treated mice
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• at E17.5 in tamoxifen-treated mice
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• reduced immature beta cells at E17.5 in tamoxifen-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in tamoxifen-treated mice
• however, induced hypoglycemia is transient
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• increased beta cell apoptosis and reduced proliferation in tamoxifen-treated mice
• beta cells from tamoxifen-treated mice exhibit glucotoxicity including increased expression of ER and oxidative stress markers compared to in control cells
• however, GFP- beta cells exhibit increased proliferation and mice treated with a selective inhibitor of calcineurin (tacrolimus; FK-506) or a GLP-1 receptor agonist (liraglutide) exhibit reduced beta cell apoptosis and dysfunction
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• reduced proliferation in tamoxifen-treated mice
• however, GFP- beta cells exhibit increased proliferation
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• reduced proliferation in tamoxifen-treated mice
• however, GFP- beta cells exhibit increased proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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