72 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ccm2Gt(RRG051)Byg/Ccm2+ involves: 129P2/OlaHsd	abnormal cell physiology	J:101748
Ccm2Gt(RRG051)Byg/Ccm2+ involves: 129P2/OlaHsd * C57BL/6J	abnormal brain vasculature morphology	J:105314
	intracranial hemorrhage	J:105314
Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg involves: 129P2/OlaHsd	abnormal cardinal vein morphology	J:146528
	abnormal dorsal aorta morphology	J:146528
	abnormal vascular endothelial cell development	J:146528
	abnormal vasculogenesis	J:146528
	dilated aortic sac	J:146528
	embryonic growth retardation	J:146528
	embryonic lethality during organogenesis, complete penetrance	J:146528
	hemopericardium	J:146528
	pericardial edema	J:146528
Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg involves: 129P2/OlaHsd * C57BL/6J	abnormal cardiovascular system morphology	J:146527
	abnormal first pharyngeal arch artery morphology	J:146527
	abnormal pharyngeal arch artery morphology	J:146527
	abnormal pharyngeal arch morphology	J:146527
	abnormal second pharyngeal arch artery morphology	J:146527
	abnormal third pharyngeal arch artery morphology	J:146527
	abnormal vitelline vascular remodeling	J:146527
	abnormal vitelline vasculature morphology	J:146527
	aorta stenosis	J:146527
	decreased angiogenesis	J:146527
	dilated dorsal aorta	J:146527
	embryonic lethality during organogenesis, complete penetrance	J:146527
	poor circulation	J:146527
	prenatal lethality, complete penetrance	J:105314
Ccm2tm1.1Etl/Ccm2tm1.1Etl B6.129-Ccm2tm1.1Etl	delayed heart development	J:146210
	embryonic lethality during organogenesis, complete penetrance	J:146210
	excessive folding of visceral yolk sac	J:146210
	pale yolk sac	J:146210
	pericardial edema	J:146210
Ccm2tm1.1Etl/Ccm2tm1Etl Tg(Cdh5-cre/ERT2)1Rha/0 involves: 129 * C57BL/6	abnormal brain vasculature morphology	J:177584
	abnormal cerebellum morphology	J:177584
	abnormal retina vasculature morphology	J:177584
	abnormal vascular endothelial cell morphology	J:177584
	cerebellum hemorrhage	J:177584
	dilated vasculature	J:177584
	postnatal lethality, complete penetrance	J:177584
	skin hemorrhage	J:177584
Ccm2tm1.1Kwhi/Ccm2tm1.1Kwhi involves: C57BL/6	abnormal cardiovascular system morphology	J:146527
	abnormal first pharyngeal arch morphology	J:146527
	abnormal pharyngeal arch morphology	J:146527
	abnormal second pharyngeal arch morphology	J:146527
	abnormal third pharyngeal arch morphology	J:146527
	abnormal vitelline vascular remodeling	J:146527
	abnormal vitelline vasculature morphology	J:146527
	aorta stenosis	J:146527
	decreased angiogenesis	J:146527
	dilated dorsal aorta	J:146527
	embryonic lethality during organogenesis, complete penetrance	J:146527
	poor circulation	J:146527
Ccm2tm1Etl/Ccm2tm1Etl involves: 129	abnormal vascular endothelial cell morphology	J:177584
Ccm2tm1Etl/Ccm2tm1Etl Tg(Nes-cre)1Kln/? B6.Cg-Ccm2tm1Etl Tg(Nes-cre)1Kln	no abnormal phenotype detected	J:146210
Ccm2tm1Etl/Ccm2tm1Etl Tg(Tek-cre)1Ywa/0 B6.Cg-Tg(Tek-cre)1Ywa Ccm2tm1Etl	abnormal atrioventricular cushion morphology	J:146210
	abnormal brain vasculature morphology	J:146210
	abnormal cardinal vein morphology	J:146210
	abnormal choroid plexus morphology	J:146210
	abnormal dorsal aorta morphology	J:146210
	abnormal placental labyrinth vasculature morphology	J:146210
	abnormal sinus venosus morphology	J:146210
	abnormal somite development	J:146210
	absent vitelline blood vessels	J:146210
	disorganized extraembryonic tissue	J:146210
	embryonic growth arrest	J:146210
	embryonic lethality during organogenesis, complete penetrance	J:146210
	enlarged heart	J:146210
	increased heart atrium size	J:146210
	pale placenta	J:146210
	pale yolk sac	J:146210
	pericardial edema	J:146210
	thin ventricular wall	J:146210
Ccm2tm1Kwhi/Ccm2tm1.1Kwhi Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	no abnormal phenotype detected	J:146527
Ccm2tm1Kwhi/Ccm2tm1.1Kwhi Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? involves: C57BL/6 * CBA	abnormal astrocyte morphology	J:173947
	abnormal brain vasculature morphology	J:173947
	abnormal pericyte morphology	J:173947
	CNS inflammation	J:173947
	postnatal lethality	J:173947
Ccm2tm1Kwhi/Ccm2tm1.1Kwhi Tg(Tagln-cre)1Jjl/0 involves: FVB/N	no abnormal phenotype detected	J:146527
Ccm2tm1Kwhi/Ccm2tm1.1Kwhi Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * SJL	abnormal cardiovascular system morphology	J:146527
	abnormal first pharyngeal arch artery morphology	J:146527
	abnormal pharyngeal arch morphology	J:146527
	abnormal second pharyngeal arch artery morphology	J:146527
	abnormal third pharyngeal arch artery morphology	J:146527
	aorta stenosis	J:146527
	decreased angiogenesis	J:146527
	dilated dorsal aorta	J:146527
	embryonic lethality during organogenesis, complete penetrance	J:146527
	poor circulation	J:146527
Ccm2tm1Kwhi/Ccm2tm1Kwhi Tg(Nes-cre)1Kln/? involves: C57BL/6 * SJL	no abnormal phenotype detected	J:173947
Ccm2tm1Mlkn/Ccm2tm1Mlkn Nfatc1tm1.1(cre)Bz/Nfatc1+ involves: 129 * 129S1/Sv * 129X1/SvJ	decreased cardiac jelly amount	J:238897
	lethality throughout fetal growth and development, complete penetrance	J:238897
	thin myocardium	J:238897
Ccm2tm1Mlkn/Ccm2tm1Mlkn Tg(Cdh5-cre/ERT2)1Rha/0 involves: 129	abnormal brain vasculature morphology	J:250906
Ccm2tm1Sbn/Ccm2tm1Sbn involves: C57BL/6	abnormal angiogenesis	J:174085
	abnormal artery development	J:174085
	abnormal developmental vascular remodeling	J:174085
	abnormal heart development	J:174085
	abnormal vascular branching morphogenesis	J:174085
	abnormal vascular smooth muscle morphology	J:174085
	abnormal vitelline vascular remodeling	J:174085
	embryonic lethality during organogenesis, complete penetrance	J:174085
	failure of heart looping	J:174085
	pericardial edema	J:174085
	short forehead	J:174085
Ccm2tm2.1Sbn/Ccm2tm2.1Sbn Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal astrocyte morphology	J:174085
	abnormal brain vasculature morphology	J:174085
	ataxia	J:174085
	cerebellum hemorrhage	J:174085
	impaired blood-brain barrier function	J:174085
	intracerebral hemorrhage	J:174085
	intracranial hemorrhage	J:174085
	microgliosis	J:174085
	premature death	J:174085
	seizures	J:174085
Ccm2tm2.1Sbn/Ccm2tm2.1Sbn Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * SJL	abnormal artery development	J:174085
	abnormal developmental vascular remodeling	J:174085
	abnormal dorsal aorta morphology	J:174085
	abnormal heart development	J:174085
	abnormal vascular branching morphogenesis	J:174085
	abnormal vascular smooth muscle morphology	J:174085
	abnormal vitelline vascular remodeling	J:174085
	embryonic growth retardation	J:174085
	failure of heart looping	J:174085