Mycbp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mycbp2
MYC binding protein 2, E3 ubiquitin protein ligase
MGI:2179432

42 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Emx1^tm1(cre)Krj/Emx1⁺ Mycbp2^tm1Adia/Mycbp2^tm1Adia involves: 129S2/SvPas * C57BL/6	abnormal axon guidance	J:125702
	abnormal corpus callosum morphology	J:125702
	abnormal hippocampus morphology	J:125702
	decreased corpus callosum size	J:125702
	enlarged lateral ventricles	J:125702
Mnx1^tm4(cre)Tmj/Mnx1⁺ Mycbp2^tm1Adia/Mycbp2^tm1Adia involves: 129S1/Sv * C57BL/6	abnormal neuromuscular synapse morphology	J:125702
	perinatal lethality, incomplete penetrance	J:125702
	normal respiratory system phenotype	J:125702
Mycbp2^em1(IMPC)Mbp/Mycbp2⁺ C57BL/6N-Mybpc2^em1(IMPC)Mbp/Ucd	abnormal eye morphology	J:211773
	abnormal heart morphology	J:211773
	anophthalmia	J:211773
	enlarged heart	J:211773
Mycbp2^em1(IMPC)Mbp/Mycbp2^em1(IMPC)Mbp C57BL/6N-Mybpc2^em1(IMPC)Mbp/Ucd	preweaning lethality, complete penetrance	J:211773
Mycbp2^m274-4Tpo/Mycbp2^m274-4Tpo involves: C57BL/6J * SSL/LeJ	decreased birth body size	J:149893
	decreased birth weight	J:149893
	hunched posture	J:149893
	neonatal lethality, complete penetrance	J:149893
	respiratory distress	J:149893
Mycbp2^magsp/Mycbp2^magsp Tg(Isl1-EGFP)1Slp/0 B6.Cg-Mycbp2^magsp Tg(Isl1-EGFP)1Slp	abnormal motor neuron innervation pattern	J:132726
Mycbp2^mgln/Mycbp2^mgln Tg(Isl1-EGFP)2Slp/0 involves: C3H * C57BL/6 * DBA/2J	abnormal motor neuron innervation pattern	J:132726
Mycbp2^mgln/Mycbp2^mgln Tg(Isl1-EGFP)1Slp/0 B6.Cg-Mycbp2^mgln Tg(Isl1-EGFP)1Slp	abnormal axon extension	J:132726
	abnormal motor neuron innervation pattern	J:132726
	abnormal motor neuron morphology	J:132726
	abnormal sensory neuron innervation pattern	J:132726
	abnormal sensory neuron morphology	J:132726
	abnormal spinal nerve morphology	J:132726
Mycbp2^mgln/Mycbp2^mgln Tg(Mnx1-GFP)1Slp/0 involves: C3H * C57BL/6 * DBA/2J	abnormal motor neuron innervation pattern	J:132726
Mycbp2^tm1.1Adia/Mycbp2^tm1.1Adia involves: C57BL/6 * FVB/N	abnormal axon guidance	J:125702
	abnormal brain internal capsule morphology	J:125702
	abnormal brain interneuron morphology	J:125702
	abnormal brain morphology	J:125702
	abnormal diaphragm morphology	J:125702
	abnormal diencephalon morphology	J:125702
	abnormal habenula morphology	J:125702
	abnormal hippocampus morphology	J:125702
	abnormal innervation	J:125702
	abnormal lateral geniculate nucleus morphology	J:125702
	abnormal midbrain morphology	J:125702
	abnormal motor neuron morphology	J:125702
	abnormal nervous system morphology	J:125702
	abnormal neuromuscular synapse morphology	J:125702
	abnormal phrenic nerve morphology	J:125702
	abnormal thalamus morphology	J:125702
	absent anterior commissure	J:125702
	decreased corpus callosum size	J:125702
	dilated lateral ventricle	J:125702
	loss of cortex neurons	J:125702
	neonatal lethality, complete penetrance	J:125702
Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc Tg(Nes-cre)1Kln/0 involves: C57BL/6 * SJL	abnormal survival	J:168745
Mycbp2^tm1.1Klsc/Mycbp2^tm1.1Klsc Tg(Scn10a-cre)1Rkun/0 involves: C57BL/6 * DBA/2	abnormal spinal cord morphology	J:168745
	decreased thermal nociceptive threshold	J:168745

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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