Ptbp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptbp2
polypyrimidine tract binding protein 2
MGI:1860489

29 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptbp2^{em1(IMPC)Hmgu}/Ptbp2⁺ C57BL/6NCrl-Ptbp2^{em1(IMPC)Hmgu}/Ieg	abnormal tooth morphology	J:211773
	abnormal vibrissa morphology	J:211773
	decreased total retina thickness	J:211773
Ptbp2^{em1(IMPC)Hmgu}/Ptbp2^{em1(IMPC)Hmgu} C57BL/6NCrl-Ptbp2^{em1(IMPC)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Ptbp2^{Gt(NPX210)Byg}/Ptbp2^{Gt(NPX210)Byg} involves: 129P2/OlaHsd	abnormal cortical ventricular zone morphology	J:185949
	abnormal neuron differentiation	J:185949
	decreased neuronal precursor cell number	J:185949
	neonatal lethality	J:185949
	premature neuronal precursor differentiation	J:185949
Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk Emx1^tm1(cre)Ito/Emx1⁺ involves: 129P2/OlaHsd * 129S2/SvPas	abnormal mitral cell morphology	J:207976
	abnormal olfactory bulb layer morphology	J:207976
	absent corpus callosum	J:207976
	decreased body size	J:207976
	enlarged lateral ventricles	J:207976
	neurodegeneration	J:207976
	neuron degeneration	J:207976
	postnatal growth retardation	J:207976
	postnatal lethality, complete penetrance	J:207976
	slow postnatal weight gain	J:207976
	small hippocampus	J:207976
	thin cerebral cortex	J:207976
Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk Tg(Nes-cre)1Kln/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal brain commissure morphology	J:207976
	abnormal brain internal capsule morphology	J:207976
	abnormal brain white matter morphology	J:207976
	abnormal olfactory tract morphology	J:207976
	cyanosis	J:207976
	neonatal lethality, complete penetrance	J:207976
Ptbp2^tm1.1Rbd/Ptbp2^tm1.1Rbd Not Specified	abnormal cortical ventricular zone morphology	J:185949
	abnormal neuron differentiation	J:185949
	decreased neuronal precursor cell number	J:185949
	neonatal lethality, complete penetrance	J:185949
	premature neuronal precursor differentiation	J:185949
Ptbp2^tm1.2Dblk/Ptbp2^tm1.2Dblk involves: 129S2/SvPas * FVB/N	neonatal lethality, complete penetrance	J:207976
	neurodegeneration	J:207976
	paralysis	J:207976
	respiratory failure	J:207976

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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