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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ptbp2
polypyrimidine tract binding protein 2
MGI:1860489
25 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
involves: 129P2/OlaHsd
abnormal cortical ventricular zone morphology J:185949
abnormal neuron differentiation J:185949
decreased neuronal precursor cell number J:185949
neonatal lethality J:185949
premature neuronal precursor differentiation J:185949
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Emx1tm1(cre)Ito/Emx1+
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal mitral cell morphology J:207976
abnormal olfactory bulb layer morphology J:207976
absent corpus callosum J:207976
decreased body size J:207976
enlarged lateral ventricles J:207976
neurodegeneration J:207976
neuron degeneration J:207976
postnatal growth retardation J:207976
postnatal lethality, complete penetrance J:207976
slow postnatal weight gain J:207976
small hippocampus J:207976
thin cerebral cortex J:207976
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL
abnormal brain commissure morphology J:207976
abnormal brain internal capsule morphology J:207976
abnormal brain white matter morphology J:207976
abnormal olfactory tract morphology J:207976
cyanosis J:207976
neonatal lethality, complete penetrance J:207976
Ptbp2tm1.1Rbd/Ptbp2tm1.1Rbd
Not Specified
abnormal cortical ventricular zone morphology J:185949
abnormal neuron differentiation J:185949
decreased neuronal precursor cell number J:185949
neonatal lethality, complete penetrance J:185949
premature neuronal precursor differentiation J:185949
Ptbp2tm1.2Dblk/Ptbp2tm1.2Dblk
involves: 129S2/SvPas * FVB/N
neonatal lethality, complete penetrance J:207976
neurodegeneration J:207976
paralysis J:207976
respiratory failure J:207976

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory