Nfat5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfat5
nuclear factor of activated T cells 5
MGI:1859333

46 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nfat5^tm1.1Itl/Nfat5^tm1.1Itl Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * FVB/N	abnormal chloride level	J:201429
	abnormal lymphatic vessel morphology	J:201429
	increased mean systemic arterial blood pressure	J:201429
Nfat5^tm1.1Joar/Nfat5^tm1.1Joar Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2 * SJL	abnormal T cell physiology	J:148271
Nfat5^{tm1b(KOMP)Wtsi}/Nfat5⁺ C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J	decreased hematocrit	J:211773
	improved glucose tolerance	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating chloride level	J:211773
	increased circulating sodium level	J:211773
Nfat5^{tm1b(KOMP)Wtsi}/Nfat5^{tm1b(KOMP)Wtsi} C57BL/6N-Nfat5^{tm1b(KOMP)Wtsi}/J	preweaning lethality, incomplete penetrance	J:211773
Nfat5^tm1Rao/Nfat5^tm1Rao B6.129-Nfat5^tm1Rao	abnormal fluid regulation	J:88636
	abnormal kidney morphology	J:88636
	abnormal kidney outer medulla inner stripe morphology	J:88636
	abnormal kidney outer medulla morphology	J:88636
	abnormal kidney pelvis morphology	J:88636
	abnormal renal tubule epithelium morphology	J:88636
	abnormal renal tubule morphology	J:88636
	dilated renal tubule	J:88636
	increased kidney apoptosis	J:88636
	kidney atrophy	J:88636
	kidney papillary atrophy	J:88636
	lethality throughout fetal growth and development, incomplete penetrance	J:88636
	postnatal growth retardation	J:88636
	postnatal lethality, incomplete penetrance	J:88636
	tubulointerstitial nephritis	J:88636
Nfat5^tm1Skc/Nfat5^tm1Skc involves: 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system physiology	J:175527
	abnormal fetal cardiomyocyte proliferation	J:175527
	abnormal myocardial trabeculae morphology	J:175527
	abnormal myocardium compact layer morphology	J:175527
	anemia	J:175527
	edema	J:175527
	lethality throughout fetal growth and development, incomplete penetrance	J:175527
	prenatal lethality, complete penetrance	J:175527
	thin ventricular wall	J:175527
Nfat5^tm1Snh/Nfat5⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal immunoglobulin level	J:91482
	decreased IgG level	J:91482
	decreased T cell proliferation	J:91482
	spleen hypoplasia	J:91482
	thymus hypoplasia	J:91482
Nfat5^tm1Snh/Nfat5^tm1Snh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	lethality throughout fetal growth and development, complete penetrance	J:91482
	perinatal lethality, complete penetrance	J:91482
Tg(CD2-Nfat5)1Snh/0 involves: BALB/c * C57BL/6	abnormal cytotoxic T cell physiology	J:80066
	abnormal T cell differentiation	J:80066
	abnormal T cell physiology	J:80066
	decreased CD4-positive, alpha-beta T cell number	J:80066
	decreased CD8-positive, alpha-beta T cell number	J:80066
	decreased splenocyte proliferation	J:80066
	decreased T cell number	J:80066
	decreased T cell proliferation	J:80066
	spleen hypoplasia	J:80066
	thymus hypoplasia	J:80066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23