Nfat5^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Nfat5^tm1.1Itl
• Name: nuclear factor of activated T cells 5; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5522568
• Synonyms: TonEBP^fl
• Gene: Nfat5 Location: Chr8:108020102-108106149 bp, + strand Genetic Position: Chr8, 53.93 cM, cytoband D2
• Alliance: Nfat5^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201429
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 4. Flp-mediated recombination removed the neomycin resistance cassette and left exon 4 floxed. (J:201429)

Generation of the Nfat5^tm1.1Itl allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfat5 Mutation: 62 strains or lines available

References

• Original: J:201429 Wiig H, et al., Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest. 2013 Jul 1;123(7):2803-15
• All: 3 reference(s)