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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfat5tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5522568
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nfat5tm1.1Itl/Nfat5tm1.1Itl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * FVB/N MGI:5522641


Genotype
MGI:5522641
cn1
Allelic
Composition
Nfat5tm1.1Itl/Nfat5tm1.1Itl
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nfat5tm1.1Itl mutation (0 available); any Nfat5 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mice fed a high salt diet

homeostasis/metabolism
• mice fed a high salt diet exhibit increased chloride ion content and concentration in the skin compared with control mice
• however, plasma levels are normal

immune system
• mice fed a high salt diet fail to exhibit an increase in lymphatic capillary density unlike control mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory