Tmprss2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmprss2
transmembrane protease, serine 2
MGI:1354381

13 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Erg^tm1.1Sho/Erg^tm1.1Sho Pten^tm1Hwu/Pten^tm1Hwu Tmprss2^tm3Sho/Tmprss2^tm3Sho Tg(Pbsn-cre)4Prb/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	increased prostate gland adenocarcinoma incidence	J:212219
	normal mortality/aging	J:212219
Pten^tm1.1Hwu/Pten⁺ Tmprss2^{tm1.1(ERG)Sho}/Tmprss2^{tm1.1(ERG)Sho} involves: 129S4/SvJae * C57BL/6 * DBA/2	increased prostate intraepithelial neoplasia incidence	J:212219
Pten^tm1.1Hwu/Pten⁺ Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho} involves: 129S4/SvJae * C57BL/6 * DBA/2	increased prostate intraepithelial neoplasia incidence	J:212219
Pten^tm1Hwu/Pten⁺ Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho} Tg(Pbsn-cre)4Prb/0 involves: 129S4/SvJae * C57BL/6 * DBA/2	increased prostate gland adenocarcinoma incidence	J:212219
	premature death	J:212219
	prostate gland cyst	J:212219
Tg(DPP4)2Nnag/0 Tmprss2^{tm1(KOMP)Vlcg}/Tmprss2^{tm1(KOMP)Vlcg} involves: C57BL/6NCr * C57BL/6NTac * DBA	abnormal cytokine secretion	J:283077
	decreased susceptibility to Coronaviridae infection	J:283077
Tg(TRAMP)8247Ng/0 Tmprss2^tm1Psn/Tmprss2^tm1Psn involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased metastatic potential	J:217920
	increased tumor growth/size	J:217920
Tmprss2^{tm1.1(ERG)Sho}/Tmprss2^{tm1.1(ERG)Sho} involves: C57BL/6 * DBA/2	normal neoplasm	J:212219
	normal reproductive system phenotype	J:212219
Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho} involves: C57BL/6 * DBA/2	abnormal testosterone level	J:212219
	normal neoplasm	J:212219
	prostate gland inflammation	J:212219
	normal reproductive system phenotype	J:212219

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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