Tor1a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tor1a
torsin family 1, member A (torsin A)
MGI:1353568

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺ Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(dlx5a-cre)1Mekk/0 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1	normal behavior/neurological phenotype	J:288753
	normal nervous system phenotype	J:288753
Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺ Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL	no abnormal phenotype detected	J:288753
Gt(ROSA)26Sor^{em1(Tor1b)Wtd}/Gt(ROSA)26Sor⁺ Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL	normal behavior/neurological phenotype	J:288753
	normal growth/size/body region phenotype	J:288753
	normal nervous system phenotype	J:288753
Tor1a^tm1Wtd/Tor1a⁺ Tor1aip1^{Gt(GST004691)Lex}/Tor1aip1⁺ involves: 129S1/Sv	abnormal cell nucleus morphology	J:160544
Tor1a^tm1Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.1Wtd Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	gliosis	J:288753
	neurodegeneration	J:288753
	postnatal growth retardation	J:288753
	premature death	J:288753
	thin cerebral cortex	J:288753
Tor1a^tm1Yql/Tor1a⁺ involves: 129S2/SvPas * C57BL/6	abnormal gait	J:104513
	abnormal locomotor behavior	J:104513
	abnormal pontine nuclei morphology	J:104513
	decreased dopamine level	J:104513
	impaired balance	J:104513
	increased locomotor activity	J:104513
Tor1a^tm1Yql/Tor1a^tm1Yql involves: 129S2/SvPas * C57BL/6	perinatal lethality, complete penetrance	J:104513
Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b⁺ Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	limb grasping	J:288753
	thin cerebral cortex	J:288753
Tor1a^tm2Wtd/Tor1a^tm3.1Wtd Tor1b^tm1.2Wtd/Tor1b^tm1.2Wtd Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	thin cerebral cortex	J:288753
Tor1a^tm3.1Wtd/Tor1a⁺ Tor1aip1^tm1.1Wtd/Tor1aip1^tm1.1Wtd Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	abnormal hepatocyte morphology	J:345574
	hepatic steatosis	J:345574
Tor1a^tm3.1Wtd/Tor1a^tm3.1Wtd Tor1aip1^tm1.1Wtd/Tor1aip1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	hepatic steatosis	J:345574
Tor1a^tm3.1Wtd/Tor1a^tm3.1Wtd Tor1aip1^tm1.1Wtd/Tor1aip1^tm1.1Wtd Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA	abnormal hepatocyte morphology	J:345574
	abnormal liver physiology	J:345574
	hepatic steatosis	J:345574

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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