Tor1b^tm1.2Wtd
Targeted Allele Detail

Summary

• Symbol: Tor1b^tm1.2Wtd
• Name: torsin family 1, member B; targeted mutation 1.2, William T Dauer
• MGI ID: MGI:6705130
• Synonyms: Tor1b^flx
• Gene: Tor1b Location: Chr2:30842971-30849027 bp, + strand Genetic Position: Chr2, 21.76 cM, cytoband B
• Alliance: Tor1b^tm1.2Wtd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to insert a loxP site, followed by a FRT-flanked neomycin resistance cassette, in opposite orientation to the gene, upstream of exon 3. A second loxP site was inserted just downstream of the coding region in exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:288753)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tor1b Mutation: 17 strains or lines available

References

• Original: J:288753 Li J, et al., TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 2020 Mar 23;9:e54285
• All: 1 reference(s)