Clic4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Clic4
chloride intracellular channel 4
MGI:1352754

28 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Clic4^tm1.1Aidi/Clic4^tm1.1Aidi involves: C57BL/6 * C57BL/6J	abnormal chemokine secretion	J:175404
	decreased body weight	J:175404
	decreased circulating interleukin-6 level	J:175404
	decreased circulating tumor necrosis factor level	J:175404
	decreased interleukin-6 secretion	J:175404
	decreased interleukin-12 secretion	J:175404
	decreased susceptibility to endotoxin shock	J:175404
	decreased susceptibility to induced morbidity/mortality	J:175404
	decreased tumor necrosis factor secretion	J:175404
	increased susceptibility to bacterial infection	J:175404
Clic4^tm1.1Thor/Clic4^tm1.1Thor Ins1^{tm1.1(cre)Thor}/Ins1⁺ involves: C57BL/6J	decreased pancreatic islet cell apoptosis	J:223517
	normal homeostasis/metabolism phenotype	J:223517
Clic4^tm1.1Yus/Clic4^tm1.1Yus involves: 129S4/SvJae * C57BL/6J	abnormal corneal wound healing	J:185541
	decreased birth body size	J:185541
	decreased keratinocyte adhesion	J:185541
	decreased keratinocyte migration	J:185541
	decreased litter size	J:185541
	delayed wound healing	J:185541
	impaired macrophage phagocytosis	J:183611
	spontaneous skin ulceration	J:185541
Clic4^tm1.1Yus/Clic4^tm1.1Yus involves: 129S4/SvJae * C57BL/6J * CD-1 * FVB/N	spontaneous skin ulceration	J:185541
Clic4^tm1Jce/Clic4^tm1Jce involves: 129S1/Sv * CD-1	abnormal angiogenesis	J:146487
	abnormal physiological neovascularization	J:146487
	abnormal retina vasculature morphology	J:146487
	abnormal vascular endothelial cell morphology	J:146487
	abnormal vascular endothelial cell physiology	J:146487
	decreased angiogenesis	J:146487
	decreased body weight	J:146487
	decreased survivor rate	J:146487
	reduced female fertility	J:146487

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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