Clic4^tm1.1Yus
Targeted Allele Detail

Summary

• Symbol: Clic4^tm1.1Yus
• Name: chloride intracellular channel 4; targeted mutation 1.1, Stuart H Yuspa
• MGI ID: MGI:5426965
• Gene: Clic4 Location: Chr4:134941280-135000071 bp, - strand Genetic Position: Chr4, 67.19 cM, cytoband D3
• Alliance: Clic4^tm1.1Yus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183611
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 1.1 kb upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted 643 downstream of exon 2. Cre mediated recombination removed exon 2 and the neo cassette. (J:185541)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clic4 Mutation: 39 strains or lines available

References

• Original: J:183611 Malik M, et al., Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6130-5
• All: 3 reference(s)