Clic4^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Clic4^tm1.1Thor
• Name: chloride intracellular channel 4; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:5763611
• Synonyms: Clic4^flox, Clic4^lox
• Gene: Clic4 Location: Chr4:134941280-135000071 bp, - strand Genetic Position: Chr4, 67.19 cM, cytoband D3
• Alliance: Clic4^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of eoxn 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:223517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clic4 Mutation: 39 strains or lines available

References

• Original: J:223517 Patel D, et al., Clic4, a novel protein that sensitizes beta-cells to apoptosis. Mol Metab. 2015 Apr;4(4):253-64
• All: 1 reference(s)