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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462
67 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Ldlrtm1Her/Ldlrtm1Her
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
abnormal cholesterol homeostasis J:184536
decreased circulating cholesterol level J:184536
decreased circulating triglyceride level J:184536
decreased physiological sensitivity to xenobiotic J:184536
increased liver cholesterol level J:184536
increased susceptibility to atherosclerosis J:184536
Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal alveolar lamellar body morphology J:234268
abnormal astrocyte morphology J:81790
abnormal brain ependyma morphology J:81790
abnormal brain vasculature morphology J:81790
abnormal brain ventricle morphology J:81790
abnormal cerebral aqueduct morphology J:81790
abnormal cholesterol homeostasis J:81790
abnormal choroid plexus morphology J:81790
abnormal lateral ventricle morphology J:81790
abnormal lipid homeostasis J:81790
abnormal lipid level J:234268
abnormal lung morphology J:234268
abnormal myelin sheath morphology J:81790
abnormal myelination J:81790
abnormal neurohypophysis median eminence morphology J:81790
abnormal pulmonary alveolar parenchyma morphology J:234268
abnormal pulmonary alveolar system morphology J:234268
abnormal spinal cord central canal morphology J:81790
abnormal substantia nigra pars reticulata morphology J:81790
abnormal third ventricle morphology J:81790
absent choroid plexus J:81790
astrocytosis J:81790
decreased neuron number J:81790
increased lung squamous cell carcinoma incidence J:234268
increased macrophage derived foam cell number J:81790, J:234268
intracranial hemorrhage J:81790
lung inflammation J:234268
neuron degeneration J:81790
premature death J:234268
respiratory distress J:234268
small fourth ventricle J:81790
small lateral ventricles J:81790
small third ventricle J:81790
Nr1h2tm1Djm/Nr1h2tm1Djm
Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac
increased liver cholesterol level J:64343
Nr1h2tm1Djm/Nr1h2tm1Djm
Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
abnormal bone marrow cell physiology J:125452
abnormal female reproductive system morphology J:120923
abnormal female reproductive system physiology J:120923
abnormal macrophage morphology J:125452
abnormal male germ cell apoptosis J:120913
abnormal male reproductive system morphology J:120923
abnormal male reproductive system physiology J:120923
abnormal myometrium morphology J:120923
abnormal parturition J:120923
abnormal seminiferous tubule morphology J:120913
abnormal Sertoli cell morphology J:120913
abnormal spermatogonia proliferation J:120913
abnormal uterus physiology J:120923
decreased circulating luteinizing hormone level J:120913
decreased circulating testosterone level J:120913
decreased testis weight J:120913
hindlimb paralysis J:120923
impaired smooth muscle contractility J:120923
increased sensitivity to induced morbidity/mortality J:81696
increased susceptibility to bacterial infection J:81696
Leydig cell hypertrophy J:120913
pregnancy-related premature death J:120923
reduced male fertility J:120913
seminiferous tubule degeneration J:120913
testicular atrophy J:120913
Nr1h3tm1Djm/Nr1h3tm1Djm
Nus1tm1.1Qrm/Nus1tm1.1Qrm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129 * C57BL/6 * DBA * SJL
normal homeostasis/metabolism phenotype J:243753
increased liver cholesterol level J:243753
Nr1h3tm1Djm/Nr1h3tm1Djm
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129S6/SvEvTac * C3H * C57BL/6
amyloid beta deposits J:122372
Tg(Fabp1-Nr1h3)#Wexi/?
Tg(Fabp1-NR1I2)#Wexi/?
involves: 129X1/SvJ * C57BL/6
enlarged liver J:135594
increased liver triglyceride level J:135594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory