88 phenotypes from 11 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mapk1tm1.1Hed/Mapk1tm1.1Hed Tg(Lck-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal enzyme/coenzyme level	J:113280
	abnormal T cell subpopulation ratio	J:113280
	decreased CD4-positive, alpha-beta T cell number	J:113280
	decreased CD8-positive, alpha-beta T cell number	J:113280
Mapk1tm1.1Kuta/Mapk1+ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	decreased body size	J:125594
	perinatal lethality, incomplete penetrance	J:125594
Mapk1tm1.1Kuta/Mapk1tm1.1Kuta involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:125594
Mapk1tm1.2Kuta/Mapk1tm1.2Kuta Tg(Nes-cre)1Kag/0 involves: 129P2/OlaHsd * C57BL/6J	abnormal maternal nurturing	J:176051
	abnormal nest building behavior	J:176051
	abnormal nursing	J:176051
	abnormal response to novel object	J:176051
	abnormal response to novelty	J:176051
	abnormal social investigation	J:176051
	astrocytosis	J:176051
	decreased anxiety-related response	J:176051
	impaired contextual conditioning behavior	J:176051
	impaired cued conditioning behavior	J:176051
	increased aggression towards mice	J:176051
	social withdrawal	J:176051
	normal taste/olfaction phenotype	J:176051
Mapk1tm1a(EUCOMM)Wtsi/Mapk1tm1a(EUCOMM)Wtsi B6Brd;B6Dnk;B6N-Tyrc-Brd Mapk1tm1a(EUCOMM)Wtsi/Wtsi	preweaning lethality, complete penetrance	J:211773
Mapk1tm1Gela/Mapk1tm1Gela H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J	abnormal extrinsic tongue muscle morphology	J:239772
	abnormal mandible morphology	J:239772
	abnormal mandibular angle morphology	J:239772
	abnormal mandibular coronoid process morphology	J:239772
	abnormal Meckel's cartilage morphology	J:239772
	abnormal tongue morphology	J:239772
	abnormal tongue muscle morphology	J:239772
	abnormal tongue position	J:239772
	complete cleft palate	J:239772
	decreased tongue size	J:239772
	failure of palatal shelf elevation	J:239772
	maxilla hypoplasia	J:239772
	micrognathia	J:239772
	neonatal lethality, complete penetrance	J:239772
	small mandible	J:239772
	small mandibular condyloid process	J:239772
	small Meckel's cartilage	J:239772
Mapk1tm1Gela/Mapk1tm1Gela H2az2Tg(Wnt1-cre)11Rth/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal thymus morphology	J:144862
	abnormal thyroid gland morphology	J:144862
	cleft palate	J:144862
	double outlet right ventricle	J:144862
	lethality throughout fetal growth and development, complete penetrance	J:144862
	mandible hypoplasia	J:144862
	persistent truncus arteriosus	J:144862
	short maxilla	J:144862
	ventricular septal defect	J:144862
Mapk1tm1Gela/Mapk1tm1Gela Osr2tm2(cre)Jian/Osr2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal craniofacial phenotype	J:239772
Mapk1tm1Gela/Mapk1tm1Gela Tg(GFAP-cre)25Mes/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal cerebral cortex morphology	J:137882
	abnormal contextual conditioning behavior	J:137882
	abnormal cued conditioning behavior	J:137882
	abnormal neuron differentiation	J:137882
	thin cerebral cortex	J:137882
Mapk1tm1Hed/Mapk1tm1Hed Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal positive T cell selection	J:113280
	decreased CD4-positive, alpha-beta T cell number	J:113280
	decreased CD8-positive, alpha-beta T cell number	J:113280
	increased double-positive T cell number	J:113280
Mapk1tm1Hed/Mapk1tm1Hed Tg(Lck-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal T cell subpopulation ratio	J:113280
	decreased double-positive T cell number	J:113280
	decreased T cell proliferation	J:113280
Mapk1tm1Kuta/Mapk1tm1.1Kuta involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:125594
Mapk1tm1Kuta/Mapk1tm1Kuta involves: 129P2/OlaHsd * C57BL/6J	abnormal contextual conditioning behavior	J:125594
	abnormal cued conditioning behavior	J:125594
	abnormal spatial learning	J:125594
	normal behavior/neurological phenotype	J:125594
	normal nervous system phenotype	J:125594
Mapk1tm1Melo/Mapk1+ involves: 129S2/SvPas	cardiac hypertrophy	J:124903
	decreased cardiac muscle contractility	J:124903
Mapk1tm1Melo/Mapk1+ involves: 129S2/SvPas * C57BL/6	preweaning lethality, incomplete penetrance	J:85868
Mapk1tm1Melo/Mapk1+ involves: C57BL/6	decreased cardiac muscle contractility	J:127872
	decreased cardiac output	J:127872
	increased cardiomyocyte apoptosis	J:127872
	increased myocardial infarct size	J:127872
Mapk1tm1Melo/Mapk1tm1Melo either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)	abnormal developmental patterning	J:85868
	abnormal polar trophectoderm morphology	J:85868
	abnormal proximal-distal axis patterning	J:85868
	abnormal rostral-caudal axis patterning	J:85868
	abnormal trophoblast layer morphology	J:85868
	abnormal visceral endoderm morphology	J:85868
	absent ectoplacental cone	J:85868
	absent extraembryonic ectoderm	J:85868
	decreased embryo size	J:85868
	disorganized extraembryonic tissue	J:85868
	embryonic lethality between implantation and somite formation, complete penetrance	J:85868
Mapk1tm1Melo/Mapk1tm1Melo Tg(CAG-EGFP)B5Nagy/0 chimera involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1	decreased fibroblast proliferation	J:162580
Mapk1tm1Moga/Mapk1tm1Moga involves: 129P2/OlaHsd * C57BL/6	abnormal placenta development	J:89903
	abnormal placental labyrinth vasculature morphology	J:89903
	embryonic growth retardation	J:89903
	embryonic lethality during organogenesis, complete penetrance	J:89903
	thin myocardium	J:89903
	thin placenta labyrinth	J:89903
Mapk1tm2Hed/Mapk1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	transmission ratio distortion	J:113280
Mapk1tm2Hed/Mapk1tm2Hed involves: 129S1/Sv * 129X1/SvJ * C57BL/6	prenatal lethality, complete penetrance	J:113280
Mapk1tm2Moga/Mapk1tm2Moga involves: 129P2/OlaHsd * C57BL/6	abnormal heart morphology	J:89903
	abnormal placenta development	J:89903
	abnormal placenta labyrinth morphology	J:89903
	abnormal placenta vasculature	J:89903
	embryonic growth retardation	J:89903
	embryonic lethality during organogenesis, complete penetrance	J:89903