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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mapk1
mitogen-activated protein kinase 1
MGI:1346858
86 phenotypes from 11 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * DBA/2
abnormal enzyme/coenzyme level J:113280
abnormal T cell subpopulation ratio J:113280
decreased CD4-positive, alpha beta T cell number J:113280
decreased CD8-positive, alpha-beta T cell number J:113280
Mapk1tm1.1Kuta/Mapk1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N
decreased body size J:125594
perinatal lethality, incomplete penetrance J:125594
Mapk1tm1.1Kuta/Mapk1tm1.1Kuta
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N
embryonic lethality during organogenesis, complete penetrance J:125594
Mapk1tm1.2Kuta/Mapk1tm1.2Kuta
Tg(Nes-cre)1Kag/0
involves: 129P2/OlaHsd * C57BL/6J
abnormal maternal nurturing J:176051
abnormal nest building behavior J:176051
abnormal nursing J:176051
abnormal response to novel object J:176051
abnormal response to novelty J:176051
abnormal social investigation J:176051
astrocytosis J:176051
decreased anxiety-related response J:176051
impaired contextual conditioning behavior J:176051
impaired cued conditioning behavior J:176051
increased aggression towards mice J:176051
social withdrawal J:176051
normal taste/olfaction phenotype J:176051
Mapk1tm1a(EUCOMM)Wtsi/Mapk1tm1a(EUCOMM)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Mapk1tm1a(EUCOMM)Wtsi/Wtsi
preweaning lethality, complete penetrance J:211773
Mapk1tm1Gela/Mapk1tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J
abnormal extrinsic tongue muscle morphology J:239772
abnormal mandible morphology J:239772
abnormal mandibular angle morphology J:239772
abnormal mandibular coronoid process morphology J:239772
abnormal Meckel's cartilage morphology J:239772
abnormal tongue morphology J:239772
abnormal tongue muscle morphology J:239772
cleft palate J:239772
decreased tongue size J:239772
failure of palatal shelf elevation J:239772
maxilla hypoplasia J:239772
micrognathia J:239772
neonatal lethality, complete penetrance J:239772
small mandible J:239772
small mandibular condyloid process J:239772
small Meckel's cartilage J:239772
Mapk1tm1Gela/Mapk1tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
abnormal thymus morphology J:144862
abnormal thyroid gland morphology J:144862
cleft palate J:144862
double outlet right ventricle J:144862
lethality throughout fetal growth and development, complete penetrance J:144862
mandible hypoplasia J:144862
persistent truncus arteriosis J:144862
short maxilla J:144862
ventricular septal defect J:144862
Mapk1tm1Gela/Mapk1tm1Gela
Osr2tm2(cre)Jian/Osr2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal craniofacial phenotype J:239772
Mapk1tm1Gela/Mapk1tm1Gela
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
abnormal cerebral cortex morphology J:137882
abnormal contextual conditioning behavior J:137882
abnormal cued conditioning behavior J:137882
abnormal neuron differentiation J:137882
thin cerebral cortex J:137882
Mapk1tm1Hed/Mapk1tm1Hed
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2
abnormal positive T cell selection J:113280
decreased CD4-positive, alpha beta T cell number J:113280
decreased CD8-positive, alpha-beta T cell number J:113280
increased double-positive T cell number J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * DBA/2
abnormal T cell subpopulation ratio J:113280
decreased double-positive T cell number J:113280
decreased T cell proliferation J:113280
Mapk1tm1Kuta/Mapk1tm1.1Kuta
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N
embryonic lethality during organogenesis, complete penetrance J:125594
Mapk1tm1Kuta/Mapk1tm1Kuta
involves: 129P2/OlaHsd * C57BL/6J
abnormal contextual conditioning behavior J:125594
abnormal cued conditioning behavior J:125594
abnormal spatial learning J:125594
normal behavior/neurological phenotype J:125594
normal nervous system phenotype J:125594
Mapk1tm1Melo/Mapk1+
involves: 129S2/SvPas
cardiac hypertrophy J:124903
decreased cardiac muscle contractility J:124903
Mapk1tm1Melo/Mapk1+
involves: 129S2/SvPas * C57BL/6
preweaning lethality, incomplete penetrance J:85868
Mapk1tm1Melo/Mapk1+
involves: C57BL/6
decreased cardiac muscle contractility J:127872
decreased cardiac output J:127872
increased cardiomyocyte apoptosis J:127872
increased myocardial infarction size J:127872
Mapk1tm1Melo/Mapk1tm1Melo
either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)
abnormal developmental patterning J:85868
abnormal polar trophectoderm morphology J:85868
abnormal proximal-distal axis patterning J:85868
abnormal rostral-caudal axis patterning J:85868
abnormal trophoblast layer morphology J:85868
abnormal visceral endoderm morphology J:85868
absent ectoplacental cone J:85868
absent extraembryonic ectoderm J:85868
decreased embryo size J:85868
disorganized extraembryonic tissue J:85868
embryonic lethality between implantation and somite formation, complete penetrance J:85868
Mapk1tm1Melo/Mapk1tm1Melo
Tg(CAG-EGFP)B5Nagy/0
chimera involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1
decreased fibroblast proliferation J:162580
Mapk1tm1Moga/Mapk1tm1Moga
involves: 129P2/OlaHsd * C57BL/6
abnormal placenta development J:89903
abnormal placental labyrinth vasculature morphology J:89903
embryonic growth retardation J:89903
embryonic lethality during organogenesis, complete penetrance J:89903
thin myocardium J:89903
thin placenta labyrinth J:89903
Mapk1tm2Hed/Mapk1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
transmission ratio distortion J:113280
Mapk1tm2Hed/Mapk1tm2Hed
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
prenatal lethality, complete penetrance J:113280
Mapk1tm2Moga/Mapk1tm2Moga
involves: 129P2/OlaHsd * C57BL/6
abnormal heart morphology J:89903
abnormal placenta development J:89903
abnormal placenta labyrinth morphology J:89903
abnormal placenta vasculature J:89903
embryonic growth retardation J:89903
embryonic lethality during organogenesis, complete penetrance J:89903

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory