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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr5a2
nuclear receptor subfamily 5, group A, member 2
MGI:1346834
36 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Albtm1(cre/ERT2)Mtz/Alb+
Nr5a2tm1Sjns/Nr5a2tm1Sjns
involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL 		abnormal bile salt level J:129068
abnormal feces composition J:129068
abnormal intestinal lipid absorption J:129068
increased bile salt level J:129068
Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd 		abnormal colon morphology J:123697
abnormal crypts of Lieberkuhn morphology J:123697
colonic necrosis J:123697
edema J:123697
increased susceptibility to induced colitis J:123697
Nr5a2tm1Auw/Nr5a2+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal crypts of Lieberkuhn morphology J:92508
Nr5a2tm1Auw/Nr5a2+
involves: C57BL/6J 		decreased circulating testosterone level J:118368
decreased epididymis weight J:118368
decreased seminal vesicle weight J:118368
Nr5a2tm1Auw/Nr5a2tm1Auw
involves: 129P2/OlaHsd * C57BL/6J 		prenatal lethality, complete penetrance J:92508
Nr5a2tm1Bel/Nr5a2+
involves: 129/Sv * C57BL/6 * SJL 		abnormal bile salt level J:89523
abnormal pregnancy J:124199
decreased circulating cholesterol level J:91695
decreased circulating progesterone level J:124199
increased uterus weight J:124199
reduced female fertility J:124199
normal reproductive system phenotype J:124199
Nr5a2tm1Bel/Nr5a2tm1Bel
involves: 129/Sv * C57BL/6 * SJL 		abnormal amniotic cavity morphology J:91695
abnormal ectoderm development J:91695
abnormal germ layer development J:91695
abnormal mesoderm development J:91695
absent amniotic cavity J:91695
embryonic lethality between implantation and somite formation, complete penetrance J:91695
Nr5a2tm1Lex/Nr5a2+
involves: 129 		prenatal lethality, incomplete penetrance J:97625
Nr5a2tm1Lex/Nr5a2tm1Lex
involves: 129 		abnormal ectoderm development J:97625
abnormal embryo development J:97625
abnormal proamniotic cavity morphology J:97625
abnormal visceral endoderm morphology J:97625
decreased embryo size J:97625
embryonic lethality between implantation and somite formation, incomplete penetrance J:97625
embryonic lethality during organogenesis, complete penetrance J:97625
Nr5a2tm1Sakl/Nr5a2tm1Sakl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA 		abnormal bile composition J:135822
decreased circulating aspartate transaminase level J:135822
decreased circulating cholesterol level J:135822
Nr5a2tm1Sakl/Nr5a2tm1Sakl
Tg(Vil1-cre)997Gum/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL 		decreased circulating aspartate transaminase level J:135822
decreased circulating cholesterol level J:135822
normal digestive/alimentary phenotype J:135822
Nr5a2tm1Sjns/Nr5a2tm1Sjns
Tg(Vil1-cre/ERT2)23Syr/?
involves: 129/Sv * C57BL/6 * DBA/2 * SJL 		colonic necrosis J:123697
increased susceptibility to induced colitis J:123697
Nr5a2tm3.1Sjns/Nr5a2tm3.1Sjns
B6J.B6N(Cg)-Nr5a2tm3.1Sjns 		abnormal bile salt homeostasis J:215556
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04/23/2024
MGI 6.23 		The Jackson Laboratory