74 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rb1cc1em1(IMPC)Mbp/Rb1cc1+ C57BL/6N-Rb1cc1em1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	embryonic growth retardation	J:211773
Rb1cc1em1(IMPC)Mbp/Rb1cc1em1(IMPC)Mbp C57BL/6N-Rb1cc1em1(IMPC)Mbp/MbpMmucd	abnormal visceral yolk sac morphology	J:211773
	abnormal vitelline vasculature morphology	J:211773
	embryonic growth retardation	J:211773
	microphthalmia	J:211773
	preweaning lethality, complete penetrance	J:211773
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan involves: 129P2/OlaHsd	abnormal enterocyte morphology	J:206181
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:114498
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd	normal immune system phenotype	J:235399
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan Tg(BEST1-cre)1Jdun/0 involves: 129P2/OlaHsd * C57BL/6	abnormal Bruch membrane morphology	J:282249
	abnormal cone electrophysiology	J:282249
	abnormal retina photoreceptor layer morphology	J:282249
	abnormal retina pigment epithelium morphology	J:282249
	abnormal retina pigmentation	J:282249
	abnormal rod electrophysiology	J:282249
	decreased b-wave amplitude	J:282249
	disorganized retina layers	J:282249
	disorganized retina outer nuclear layer	J:282249
	impaired autophagy	J:282249
	increased susceptibility to age-related retinal degeneration	J:282249
	lipofuscinosis	J:282249
	microgliosis	J:282249
	retina pigment epithelium atrophy	J:282249
	thin retina outer nuclear layer	J:282249
	normal vision/eye phenotype	J:282249
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan Tg(Mx1-cre)1Cgn/0 B6.Cg-Rb1cc1tm1.1Guan Tg(Mx1-cre)1Cgn	abnormal hematopoietic stem cell morphology	J:167258
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan Tg(SFTPC-cre)11Yo/0 involves: 129P2/OlaHsd * C57BL/6	abnormal alveolar lamellar body morphology	J:300057
	cyanosis	J:300057
	decreased alveolar lamellar body number	J:300057
	neonatal lethality, complete penetrance	J:300057
	respiratory distress	J:300057
	respiratory failure	J:300057
	small alveolar lamellar bodies	J:300057
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv/0 B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv	abnormal autophagy	J:167258
	abnormal erythropoiesis	J:167258
	abnormal liver morphology	J:167258
	abnormal mitochondrial morphology	J:167258
	abnormal myelopoiesis	J:167258
	anemia	J:167258
	normal cardiovascular system phenotype	J:167258
	decreased erythrocyte cell number	J:167258
	decreased hematocrit	J:167258
	decreased hematopoietic stem cell number	J:167258
	decreased hemoglobin content	J:167258
	normal homeostasis/metabolism phenotype	J:167258
	increased erythroblast number	J:167258
	increased hematopoietic stem cell proliferation	J:167258
	increased neutrophil cell number	J:167258
	increased red blood cell distribution width	J:167258
	lethality throughout fetal growth and development, incomplete penetrance	J:167258
	pale liver	J:167258
	postnatal lethality, complete penetrance	J:167258
Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan involves: 129P2/OlaHsd * C57BL/6	abnormal heart morphology	J:114498
	abnormal heart ventricle morphology	J:114498
	abnormal hepatocyte morphology	J:114498
	abnormal liver morphology	J:114498
	abnormal myocardial trabeculae morphology	J:114498
	abnormal myocardium compact layer morphology	J:114498
	abnormal myocardium layer morphology	J:114498
	abnormal trabecula carnea morphology	J:114498
	congestive heart failure	J:114498
	decreased cell mass	J:114498
	decreased hepatocyte number	J:114498
	dilated heart left ventricle	J:114498
	dissociated hepatocytes	J:114498
	edema	J:114498
	increased fibroblast apoptosis	J:114498
	increased hepatocyte apoptosis	J:114498
	lethality throughout fetal growth and development, complete penetrance	J:114498
	liver degeneration	J:114498
	liver hemorrhage	J:114498
	pallor	J:114498
	thin myocardium	J:114498
	thin ventricular wall	J:114498