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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rb1cc1
RB1-inducible coiled-coil 1
MGI:1341850
77 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Rb1cc1em1(IMPC)Mbp/Rb1cc1+
C57BL/6N-Rb1cc1em1(IMPC)Mbp/MbpMmucd
abnormal embryo turning J:211773
abnormal forebrain development J:211773
abnormal heart looping J:211773
abnormal heart morphology J:211773
abnormal hindbrain development J:211773
abnormal midbrain development J:211773
abnormal neural tube closure J:211773
abnormal neural tube morphology J:211773
abnormal otic vesicle morphology J:211773
abnormal pericardium morphology J:211773
abnormal pharyngeal arch morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
decreased exploration in new environment J:211773
increased prepulse inhibition J:211773
Rb1cc1em1(IMPC)Mbp/Rb1cc1em1(IMPC)Mbp
C57BL/6N-Rb1cc1em1(IMPC)Mbp/MbpMmucd
abnormal craniofacial morphology J:211773
abnormal heart morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
abnormal visceral yolk sac morphology J:211773
preweaning lethality, complete penetrance J:211773
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
involves: 129P2/OlaHsd
abnormal enterocyte morphology J:206181
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:114498
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd
normal immune system phenotype J:235399
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Tg(BEST1-cre)1Jdun/0
involves: 129P2/OlaHsd * C57BL/6
abnormal Bruch membrane morphology J:282249
abnormal cone electrophysiology J:282249
abnormal retinal photoreceptor layer morphology J:282249
abnormal retinal pigment epithelium morphology J:282249
abnormal retinal pigmentation J:282249
abnormal rod electrophysiology J:282249
decreased b-wave amplitude J:282249
disorganized retinal layers J:282249
disorganized retinal outer nuclear layer J:282249
impaired autophagy J:282249
lipofuscinosis J:282249
microgliosis J:282249
retinal degeneration J:282249
retinal pigment epithelium atrophy J:282249
thin retinal outer nuclear layer J:282249
normal vision/eye phenotype J:282249
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Tg(Mx1-cre)1Cgn/0
B6.Cg-Rb1cc1tm1.1Guan Tg(Mx1-cre)1Cgn
abnormal hematopoietic stem cell morphology J:167258
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Tg(Tek-cre)12Flv/0
B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv
abnormal autophagy J:167258
abnormal erythropoiesis J:167258
abnormal liver morphology J:167258
abnormal mitochondrial morphology J:167258
abnormal myelopoiesis J:167258
anemia J:167258
normal cardiovascular system phenotype J:167258
decreased erythrocyte cell number J:167258
decreased hematocrit J:167258
decreased hematopoietic stem cell number J:167258
decreased hemoglobin content J:167258
normal homeostasis/metabolism phenotype J:167258
increased erythroblast number J:167258
increased hematopoietic stem cell proliferation J:167258
increased neutrophil cell number J:167258
increased red blood cell distribution width J:167258
lethality throughout fetal growth and development, incomplete penetrance J:167258
pale liver J:167258
postnatal lethality, complete penetrance J:167258
Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan
involves: 129P2/OlaHsd * C57BL/6
abnormal heart morphology J:114498
abnormal heart ventricle morphology J:114498
abnormal hepatocyte morphology J:114498
abnormal liver morphology J:114498
abnormal myocardial trabeculae morphology J:114498
abnormal myocardium compact layer morphology J:114498
abnormal myocardium layer morphology J:114498
abnormal trabecula carnea morphology J:114498
congestive heart failure J:114498
decreased cell mass J:114498
decreased hepatocyte number J:114498
dilated heart left ventricle J:114498
dissociated hepatocytes J:114498
edema J:114498
increased fibroblast apoptosis J:114498
increased hepatocyte apoptosis J:114498
lethality throughout fetal growth and development, complete penetrance J:114498
liver degeneration J:114498
liver hemorrhage J:114498
pallor J:114498
thin myocardium J:114498
thin ventricular wall J:114498

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory