Lancl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lancl1
LanC (bacterial lantibiotic synthetase component C)-like 1
MGI:1336997

28 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lancl1^em1Vdd/Lancl1^em1Vdd FVB/N-Lancl1^em1Vdd	no abnormal phenotype detected	J:249809
Lancl1^tm1.1Pfw/Lancl1^tm1.1Pfw involves: 129 * C57BL/6	abnormal cauda epididymis morphology	J:324139
	abnormal mitochondrial physiology	J:214805
	abnormal redox activity	J:324139
	abnormal seminiferous tubule morphology	J:324139
	abnormal sperm mitochondrial sheath morphology	J:324139
	abnormal sperm physiology	J:324139
	abnormal spermatocyte morphology	J:324139
	abnormal spermatogenesis	J:324139
	abnormal spermatogonia morphology	J:324139
	abnormal spermatogonia proliferation	J:324139
	asthenozoospermia	J:324139
	brain inflammation	J:214805
	decreased litter size	J:324139
	decreased male germ cell number	J:324139
	decreased sperm progressive motility	J:324139
	decreased testis weight	J:324139
	dilated mitochondrion	J:324139
	normal homeostasis/metabolism phenotype	J:324139
	increased male germ cell apoptosis	J:324139
	increased neuron apoptosis	J:214805
	increased susceptibility to neuronal excitotoxicity	J:214805
	increased testis weight	J:324139
	neurodegeneration	J:214805
	oligozoospermia	J:324139
	oxidative stress	J:214805, J:324139
	reduced male fertility	J:324139
	testicular atrophy	J:324139
Lancl1^tm1Pfw/Lancl1^tm1.1Pfw Tg(Ddx4-cre)1Dcas/0 involves: 129 * C57BL/6 * FVB	abnormal sperm physiology	J:324139
	abnormal spermatogenesis	J:324139
	asthenozoospermia	J:324139
	decreased male germ cell number	J:324139
	decreased sperm progressive motility	J:324139
	decreased testis weight	J:324139
	oligozoospermia	J:324139
	oxidative stress	J:324139
	reduced male fertility	J:324139

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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