Lancl1^tm1.1Pfw
Targeted Allele Detail

Summary

• Symbol: Lancl1^tm1.1Pfw
• Name: LanC (bacterial lantibiotic synthetase component C)-like 1; targeted mutation 1.1 Paul Worley
• MGI ID: MGI:5646273
• Synonyms: LanCL1 KO
• Gene: Lancl1 Location: Chr1:67039676-67078031 bp, - strand Genetic Position: Chr1, 33.75 cM, cytoband C2-C5
• Alliance: Lancl1^tm1.1Pfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214805
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a pgk-neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed exon 4 and the neo cassette. (J:214805)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lancl1 Mutation: 20 strains or lines available

References

• Original: J:214805 Huang C, et al., Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Dev Cell. 2014 Aug 25;30(4):479-87
• All: 2 reference(s)