Lancl1^em1Vdd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lancl1^em1Vdd
• Name: LanC (bacterial lantibiotic synthetase component C)-like 1; endonuclease-mediated mutation 1, Wilfred van der Donk
• MGI ID: MGI:5804191
• Gene: Lancl1 Location: Chr1:67039676-67078031 bp, - strand Genetic Position: Chr1, 33.75 cM, cytoband C2-C5
• Alliance: Lancl1^em1Vdd page

Mutation origin

• Strain of Origin: FVB/NHsd

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Pronuclear-stage embryos were targeted with a zinc finger nuclease pair designed to target exon 3. A founder mouse was identified carrying a 19-bp deletion at the targeted site (CTCGGGatggcactgggtacactggCTGGGCAG -> CTCGGGCTGGGCAG), which causes a reading frame shift resulting in a premature stop codon. Absence of the protein in brain, heart and liver of homozygous mutant mice was confirmed by immunoblot analysis. (J:249809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lancl1 Mutation: 20 strains or lines available

References

• Original: J:249809 He C, et al., LanCL proteins are not Involved in Lanthionine Synthesis in Mammals. Sci Rep. 2017 Jan 20;7:40980
• All: 2 reference(s)