34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atmtm1Pmc/Atm+ Lig4tm1Icrf/Lig4tm1Icrf either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	increased neuron apoptosis	J:65540
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4+ either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	increased neuron apoptosis	J:65540
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4tm1Icrf either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	decreased body size	J:65540
	decreased neuron apoptosis	J:65540, J:111068
	neonatal lethality, complete penetrance	J:65540, J:111068
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4tm1Icrf involves: 129	decreased cellular sensitivity to ionizing radiation	J:144172
	perinatal lethality	J:144172
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/SvImJ * C57BL/6 * SJL	ataxia	J:144172
	normal nervous system phenotype	J:144172
Cdkn2atm1Rdp/Cdkn2a+ Lig4tm1Fwa/Lig4tm1Fwa involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL	decreased cell proliferation	J:63078
	increased cellular sensitivity to ionizing radiation	J:63078
	increased neuron apoptosis	J:63078
	prenatal lethality, complete penetrance	J:63078
Cdkn2atm1Rdp/Cdkn2atm1Rdp Lig4tm1Fwa/Lig4tm1Fwa involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL	decreased cell proliferation	J:63078
	prenatal lethality, complete penetrance	J:63078
Ightm2Cgn/Ightm2Cgn Igktm1Rsky/Igktm1Rsky Lig4tm1Fwa/Lig4tm1Fwa Trp53tm1Tyj/Trp53tm1Tyj involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac	abnormal class switch recombination	J:126758
Lig4tm1Fwa/Lig4tm1Fwa Tg(Cr2-cre)3Cgn/0 Xrcc4tm2Fwa/Xrcc4tm2Fwa involves: 129S6/SvEvTac	abnormal class switch recombination	J:126758
	increased cellular sensitivity to ionizing radiation	J:126758
	spontaneous chromosome breakage	J:126758
Lig4tm1Fwa/Lig4tm1Fwa Trp53tm1Brd/Trp53+ involves: 129S6/SvEvTac * 129S7/SvEvBrd	decreased body weight	J:63078
	decreased neuron apoptosis	J:63078
	premature death	J:63078
	prenatal lethality, incomplete penetrance	J:63078
Lig4tm1Fwa/Lig4tm1Fwa Trp53tm1Brd/Trp53tm1Brd involves: 129S6/SvEvTac * 129S7/SvEvBrd	decreased body weight	J:63078
	decreased neuron apoptosis	J:63078
	decreased thymocyte number	J:63078
	increased B cell number	J:63078
	increased cellular sensitivity to ionizing radiation	J:63078
	increased fibroblast proliferation	J:63078
	increased lymphoma incidence	J:63078
	premature death	J:63078
	prenatal lethality, incomplete penetrance	J:63078
Lig4tm1Icrf/Lig4tm1Icrf Mre11atm1Jpt/Mre11atm1Jpt involves: 129 * 129S7/SvEvBrd	decreased cellular sensitivity to ionizing radiation	J:144172
	neonatal lethality, complete penetrance	J:144172
Lig4tm1Icrf/Lig4tm1Icrf Nbntm1Jpt/Nbntm1Jpt involves: 129 * 129S7/SvEvBrd	normal cellular phenotype	J:144172
	prenatal lethality, complete penetrance	J:144172
Lig4tm1Icrf/Lig4tm1Icrf Nbntm2.1Jpt/Nbntm2.1Jpt involves: 129	perinatal lethality, complete penetrance	J:144172
Lig4tm1Icrf/Lig4tm1Icrf Trp53tm1Tyj/Trp53+ either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	decreased tumor incidence	J:111068
	perinatal lethality, incomplete penetrance	J:111068
	premature death	J:111068
Lig4tm1Icrf/Lig4tm1Icrf Trp53tm1Tyj/Trp53tm1Tyj either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	increased B cell derived lymphoma incidence	J:111068
	increased medulloblastoma incidence	J:111068
Lig4tm1Pmc/Lig4tm1Pmc Mre11atm1Jpt/Mre11atm1Jpt Tg(Nes-cre)1Kln/0 involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL	ataxia	J:144172
	normal nervous system phenotype	J:144172
Lig4tm1Pmc/Lig4tm1Pmc Nbntm1Jpt/Nbntm1Jpt Tg(Nes-cre)1Kln/0 involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL	abnormal brain development	J:144172
	decreased brain weight	J:144172
	microcephaly	J:144172
Lig4tm1Pmc/Lig4tm1Pmc Trp53tm1Tyj/Trp53+ Xrcc2tm2Pmc/Xrcc2tm2Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	abnormal tumor morphology	J:144617
	increased medulloblastoma incidence	J:144617
	premature death	J:144617
Lig4tm1Pmc/Lig4tm1Pmc Trp53tm1Tyj/Trp53tm1Tyj Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	increased medulloblastoma incidence	J:144617
	premature death	J:144617
Lig4tm1Pmc/Lig4tm1Pmc Trp53tm1Tyj/Trp53tm1Tyj Xrcc2tm2Pmc/Xrcc2tm2Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	increased medulloblastoma incidence	J:144617
	premature death	J:144617
Paxxem1Spj/Paxxem1Spj Lig4tm1Fwa/Lig4tm1Fwa involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	prenatal lethality, complete penetrance	J:236776
Xrcc5tm1Dbr/Xrcc5+ Lig4tm1Fwa/Lig4+ involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
Xrcc5tm1Dbr/Xrcc5tm1Dbr Lig4tm1Fwa/Lig4tm1Fwa involves: 129S6/SvEvTac * C57BL/6	abnormal lymphocyte morphology	J:80467
	abnormal small intestine morphology	J:80467
	chromosome breakage	J:80467
	normal mortality/aging	J:80467
	prenatal lethality, incomplete penetrance	J:80467