Ppp2ca Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
MGI:1321159

35 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppp2ca^tm1.1Jmli/Ppp2ca⁺ involves: C57BL/6J	no abnormal phenotype detected	J:222054
Ppp2ca^tm1.1Jmli/Ppp2ca^tm1.1Jmli involves: C57BL/6J	no abnormal phenotype detected	J:222054
Ppp2ca^tm1.1Jmli/Ppp2ca^tm1.2Jmli Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	abnormal cauda epididymis morphology	J:222054
	abnormal seminiferous tubule morphology	J:222054
	abnormal spermatogenesis	J:222054
	arrest of male meiosis	J:222054
	decreased testis weight	J:222054
	male infertility	J:222054
	seminiferous tubule degeneration	J:222054
	small testis	J:222054
Ppp2ca^tm1.1Nju/Ppp2ca^tm1.1Nju involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:184036
Ppp2ca^tm1.1Nju/Ppp2ca^tm1.1Nju Tg(Tek-cre)12Flv/0 involves: 129S6/SvEvTac * C57BL/6	abnormal erythrocyte physiology	J:171578
	abnormal erythropoiesis	J:171578
	abnormal liver morphology	J:171578
	anemia	J:171578
	normal cardiovascular system phenotype	J:171578
	decreased fetal derived definitive erythrocyte cell number	J:171578
	embryonic lethality during organogenesis, incomplete penetrance	J:171578
	increased hematopoietic stem cell number	J:171578
	lethality throughout fetal growth and development, incomplete penetrance	J:171578
	pale liver	J:171578
	pallor	J:171578
Ppp2ca^tm1.2Nju/Ppp2ca^tm1.2Nju involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N	abnormal embryo development	J:184036
	absent mesoderm	J:184036
	decreased embryo size	J:184036
	embryonic lethality during organogenesis, complete penetrance	J:184036
Ppp2ca^tm1Gotz/Ppp2ca^tm1Gotz involves: 129/Sv * C57BL/6	abnormal embryonic tissue morphology	J:50519
	absent mesoderm	J:50519
	decreased embryo size	J:50519
	normal embryo phenotype	J:50519
	embryonic lethality between implantation and somite formation, complete penetrance	J:50519
Tg(CD2-Ppp2ca)#Gct/0 involves: C57BL/6J	abnormal T cell subpopulation ratio	J:184067
	enlarged lymph nodes	J:184067
	enlarged spleen	J:184067
	glomerulonephritis	J:184067
	increased germinal center B cell number	J:184067
	increased interleukin-17 secretion	J:184067
	increased neutrophil cell number	J:184067
	increased susceptibility to injury	J:184067

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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