Fpr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fpr2
formyl peptide receptor 2
MGI:1278319

35 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fpr2^tm1.1Jimw/Fpr2^tm1.1Jimw Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129X1/SvJ	decreased susceptibility to induced colitis	J:197568
Fpr2^tm1.1Jimw/Fpr2^tm1.1Jimw Tg(Vil1-cre)997Gum/0 involves: 129X1/SvJ * C57BL/6J * SJL	abnormal large intestine crypts of Lieberkuhn morphology	J:197568
Fpr2^tm1.2Jimw/Fpr2^tm1.2Jimw B6.129X1-Fpr2^tm1.2Jimw	abnormal bone marrow cell physiology	J:160074
	abnormal cytokine secretion	J:160074
	abnormal dendritic cell physiology	J:160074
	abnormal innate immunity	J:160074
	decreased dendritic cell number	J:160074
	decreased IgE level	J:160074
	decreased IgG1 level	J:160074
	decreased IgG2b level	J:160074
	decreased immunoglobulin level	J:160074
	decreased inflammatory response	J:160074
	decreased interferon-gamma secretion	J:160074
	decreased interleukin-2 secretion	J:160074
	decreased interleukin-4 secretion	J:160074
	decreased interleukin-5 secretion	J:160074
	decreased interleukin-13 secretion	J:160074
	decreased respiratory mucosa goblet cell number	J:160074
	impaired macrophage chemotaxis	J:160074
	impaired neutrophil chemotaxis	J:160074
	small lymph nodes	J:160074
Fpr2^tm1.2Jimw/Fpr2^tm1.2Jimw involves: 129X1/SvJ	abnormal colon morphology	J:197568
	abnormal dendritic cell chemotaxis	J:199611
	abnormal dendritic cell physiology	J:199611
	abnormal enterocyte proliferation	J:197568
	abnormal large intestine crypts of Lieberkuhn morphology	J:197568
	colitis	J:197568
	decreased acute inflammation	J:197568
	decreased dendritic cell number	J:199611
	increased colon adenoma incidence	J:197568
	increased incidence of tumors by chemical induction	J:197568
	increased susceptibility to xenobiotic induced morbidity/mortality	J:197568
	intestinal ulcer	J:197568
Fpr2^tm1Rjf/Fpr2^tm1Rjf involves: 129S/SvEv * C57BL/6	abnormal neutrophil physiology	J:159658
	abnormal response to injury	J:159658
	impaired macrophage chemotaxis	J:159658
	increased acute inflammation	J:159658
	increased susceptibility to induced arthritis	J:159658
Tg(ACTB-Fpr2)#Jimw/0 involves: FVB	abnormal dendritic cell physiology	J:160074
Tg(ACTB-Fpr2)#Jimw/0 involves: FVB	respiratory system inflammation	J:160074

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23