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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Itch
itchy, E3 ubiquitin protein ligase
MGI:1202301
54 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Itchtm1(NCOM)Cmhd/Itch+
C57BL/6N-Itchtm1(NCOM)Cmhd/Tcp
increased mean corpuscular volume J:165965
Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal immunoglobulin level J:204685
abnormal interleukin secretion J:204685
abnormal lymph organ size J:204685
abnormal lymphopoiesis J:204685
abnormal regulatory T cell physiology J:204685
abnormal T-helper 2 cell differentiation J:204685
abnormal T-helper 2 physiology J:204685
decreased CD4-positive, alpha beta T cell number J:204685
dermatitis J:204685
enlarged lymph nodes J:204685
enlarged spleen J:204685
normal immune system phenotype J:204685
increased CD4-positive, alpha beta T cell number J:204685
increased CD8-positive, alpha-beta T cell number J:204685
increased eosinophil cell number J:204685
increased IgA level J:204685
increased IgE level J:204685
increased IgG1 level J:204685
increased inflammatory response J:204685
increased interleukin-4 secretion J:204685
increased interleukin-5 secretion J:204685
increased interleukin-10 secretion J:204685
increased interleukin-13 secretion J:204685
increased interleukin-17 secretion J:204685
increased leukocyte cell number J:204685
increased regulatory T cell apoptosis J:204685
increased regulatory T cell number J:204685
lung inflammation J:204685
premature death J:204685
skin lesions J:204685
weight loss J:204685
Itchtm1b(EUCOMM)Hmgu/Itchtm1b(EUCOMM)Hmgu
C57BL/6N-Itchtm1b(EUCOMM)Hmgu/H
abnormal behavior J:211773
abnormal bone structure J:211773
abnormal tooth morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased circulating alkaline phosphatase level J:211773
decreased circulating cholesterol level J:211773
decreased circulating fructosamine level J:211773
decreased circulating glucose level J:211773
decreased circulating HDL cholesterol level J:211773
decreased fasted circulating glucose level J:211773
decreased grip strength J:211773
decreased heart weight J:211773
decreased lean body mass J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular volume J:211773
decreased total body fat amount J:211773
increased circulating calcium level J:211773
increased circulating phosphate level J:211773
increased circulating total protein level J:211773
increased heart weight J:211773
tremors J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory