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Itch Gene Detail
Summary
  • Symbol
    Itch
  • Name
    itchy, E3 ubiquitin protein ligase
  • Synonyms
    6720481N21Rik, 8030492O04Rik, AIP4, C230047C07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202301
    NCBI Gene: 16396
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154975429-155068775 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202301
protein coding gene Chr2:154975401-155068775 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026729
protein coding gene Chr2:159930691-160029598 (+)
A/J MGP_AJ_G0026695
protein coding gene Chr2:153582092-153673943 (+)
AKR/J MGP_AKRJ_G0026666
protein coding gene Chr2:158044965-158139697 (+)
BALB/cJ MGP_BALBcJ_G0026704
protein coding gene Chr2:153892237-153978509 (+)
C3H/HeJ MGP_C3HHeJ_G0026447
protein coding gene Chr2:158388906-158493674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027153
protein coding gene Chr2:164631709-164729134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024523
protein coding gene Chr2:147083942-147176206 (+)
CAST/EiJ MGP_CASTEiJ_G0025908
protein coding gene Chr2:158695126-158795175 (+)
CBA/J MGP_CBAJ_G0026424
protein coding gene Chr2:170608230-170724854 (+)
DBA/2J MGP_DBA2J_G0026561
protein coding gene Chr2:152763479-152862043 (+)
FVB/NJ MGP_FVBNJ_G0026528
protein coding gene Chr2:151144432-151243818 (+)
LP/J MGP_LPJ_G0026666
protein coding gene Chr2:160069731-160164608 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026549
protein coding gene Chr2:174613368-174717762 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027209
protein coding gene Chr2:157912661-158013549 (+)
PWK/PhJ MGP_PWKPhJ_G0025642
protein coding gene Chr2:152261171-152356219 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025445
protein coding gene Chr2:156857360-156957011 (+)
WSB/EiJ MGP_WSBEiJ_G0025978
protein coding gene Chr2:158811240-158905698 (+)



Homology
more
  • Human Ortholog
    ITCH, itchy E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITCH, itchy E3 ubiquitin protein ligase
  • Synonyms
    ADMFD, AIF4, AIP4, NAPP1
  • Links
    NCBI Gene ID: 83737
    neXtProt AC: NX_Q96J02
    UniProt: Q96J02

  • Chr Location
    20q11.22; chr20:34363235-34511773 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU mutation exhibit increased total IgE levels in the peripheral blood and an enhanced IgE response to the cysteine protease allergen, papain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027598 Ensembl Gene Model | MGI Sequence Detail 93347 C57BL/6J ±  kb
    transcript ENSMUST00000029126 Ensembl | MGI Sequence Detail 5159 Not Applicable  
    polypeptide ENSMUSP00000029126 Ensembl | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 4
      cDNA 28
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924982, MGI:2441729, MGI:2443666
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 8
      Gene Ontology 18
      Phenotypes 53
    • Earliest
      J:24934 Hustad CM, et al., Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics. 1995 May;140(1):255-65
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory