143 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Esr2tm1.1Gust/Esr2tm1.1Gust B6J.129X1(Cg)-Esr2tm1.1Gust	abnormal tertiary ovarian follicle morphology	J:220968
	absent corpus luteum	J:220968
	absent mature ovarian follicles	J:220968
	anovulation	J:220968
	female infertility	J:220968
	increased atretic ovarian follicle number	J:220968
	increased secondary ovarian follicle number	J:220968
	normal reproductive system phenotype	J:220968
Esr2tm1.1Ksk/Esr2tm1.1Ksk involves: C57BL/6	decreased ovulation rate	J:198474
	failure of superovulation	J:198474
	reduced female fertility	J:198474
Esr2tm1.1Pcn/Esr2tm1.1Pcn Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * 129S2/SvPas	delayed wound healing	J:165719
Esr2tm1.1Pcn/Esr2tm1.1Pcn Tg(KRT14-cre)1Ipc/0 involves: 129S2/SvPas * C57BL/6 * SJL	delayed wound healing	J:165719
Esr2tm1.2Pcn/Esr2tm1.2Pcn involves: 129S2/SvPas * C57BL/6 * SJL	abnormal estrous cycle	J:132171
	normal cardiovascular system phenotype	J:132171
	decreased corpora lutea number	J:132171
	normal digestive/alimentary phenotype	J:132171
	failure of superovulation	J:132171
	female infertility	J:132171
	normal immune system phenotype	J:132171
	increased atretic ovarian follicle number	J:132171
	male infertility	J:132171
	normal nervous system phenotype	J:132171
	normal renal/urinary system phenotype	J:132171
	normal reproductive system phenotype	J:132171
	normal respiratory system phenotype	J:132171
Esr2tm1Dgen/Esr2tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:82809
Esr2tm1Mma/Esr2+ involves: 129S2/SvPas	abnormal germ cell morphology	J:105626
	normal reproductive system phenotype	J:105626
Esr2tm1Mma/Esr2tm1Mma involves: 129S2/SvPas	abnormal bone ossification	J:123373
	abnormal germ cell morphology	J:105626
	abnormal response/metabolism to endogenous compounds	J:64426
	decreased corpora lutea number	J:64426
	decreased volumetric bone mineral density	J:123373
	delayed wound healing	J:165719
	normal homeostasis/metabolism phenotype	J:123373
	increased bone strength	J:123373
	increased neutrophil cell number	J:165719
	increased total body fat amount	J:123373
	reduced female fertility	J:64426
	normal renal/urinary system phenotype	J:64426
	normal reproductive system phenotype	J:64426, J:105626
	short ulna	J:123373
	normal skeleton phenotype	J:123373
Esr2tm1Mma/Esr2tm1Mma involves: 129S2/SvPas * C57BL/6	abnormal synaptic plasticity	J:72240
	decreased chemical nociceptive threshold	J:130786
	decreased locomotor activity	J:72240
	decreased vertical activity	J:72240
	increased anxiety-related response	J:72240
	increased thigmotaxis	J:72240
Esr2tm1Unc/Esr2tm1Unc B6.129P2-Esr2tm1Unc	abnormal nociception after inflammation	J:151022
	decreased dopamine level	J:101943
	decreased exploration in new environment	J:101943
	decreased serotonin level	J:101943
	hyporesponsive to tactile stimuli	J:151022
	increased anxiety-related response	J:101943
Esr2tm1Unc/Esr2tm1Unc involves: 129P2/OlaHsd	abnormal auditory brainstem response	J:135833
	abnormal behavior	J:151012
	abnormal enterocyte morphology	J:107308
	abnormal enterocyte physiology	J:107308
	abnormal enterocyte proliferation	J:107308
	abnormal excitatory postsynaptic potential	J:115451
	abnormal intercalated disk morphology	J:93438
	abnormal large intestine crypts of Lieberkuhn morphology	J:107308
	abnormal long bone epiphyseal plate morphology	J:111108
	abnormal mammary gland epithelium morphology	J:125583
	abnormal mammary gland growth during lactation	J:125583
	abnormal mammary gland growth during pregnancy	J:125583
	abnormal muscle contractility	J:95398
	abnormal myocardial fiber morphology	J:93438
	abnormal pulmonary alveolus morphology	J:89974
	abnormal response to cardiac infarction	J:108991
	abnormal response/metabolism to endogenous compounds	J:64165
	abnormal surfactant physiology	J:89974
	abnormal urinary bladder morphology	J:122274
	abnormal urinary bladder physiology	J:122274
	abnormal urinary bladder urothelium morphology	J:122274
	ascites	J:108991
	cardiac hypertrophy	J:93438
	colitis	J:107308
	decreased circulating glucose level	J:151012
	decreased enterocyte apoptosis	J:107308
	decreased insulin secretion	J:151012
	dilated heart ventricle	J:93438
	enlarged heart	J:93438
	enlarged pancreatic islets	J:151012
	impaired contextual conditioning behavior	J:115451
	impaired cued conditioning behavior	J:115451
	increased body length	J:111108
	increased body weight	J:108991
	increased circulating glucose level	J:151012
	increased heart weight	J:108991
	increased insulin sensitivity	J:151012
	increased myocardial fiber size	J:93438
	increased susceptibility to induced morbidity/mortality	J:108991
	increased urine glycosaminoglycan level	J:122274
	increased vasodilation	J:64165
	long femur	J:111108
	mammary gland alveolar hyperplasia	J:125583
	reduced long-term potentiation	J:115451
	urinary bladder inflammation	J:122274
Esr2tm1Unc/Esr2tm1Unc involves: 129P2/OlaHsd * C57BL/6	abnormal response of heart to induced stress	J:101968
	decreased physiological sensitivity to xenobiotic	J:101968
	increased circulating luteinizing hormone level	J:118736
Esr2tm1Unc/Esr2tm1Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal astrocyte morphology	J:67862
	abnormal B cell number	J:82423
	abnormal bone marrow cell number	J:82423
	abnormal bone mineralization	J:91765
	abnormal cochlear IHC afferent innervation pattern	J:108892
	abnormal cumulus oophorus morphology	J:51663
	abnormal hair cycle catagen phase	J:107589
	abnormal leukopoiesis	J:83617
	abnormal lung morphology	J:83617
	abnormal lymphopoiesis	J:83617
	abnormal muscle electrophysiology	J:73898
	abnormal neocortex morphology	J:67862
	abnormal response/metabolism to endogenous compounds	J:82423, J:110416
	abnormal sexual interaction	J:66582
	abnormal somatosensory cortex morphology	J:67862
	abnormal spatial learning	J:75472
	abnormal substantia nigra morphology	J:67862
	abnormal superovulation	J:51663
	abnormal urinary bladder urothelium morphology	J:51663
	abnormal vascular smooth muscle morphology	J:73898
	abnormal vascular smooth muscle physiology	J:73898
	accelerated hair follicle regression	J:107589
	anemia	J:83617
	astrocytosis	J:67862
	normal behavior/neurological phenotype	J:65785
	decreased brain size	J:67862
	decreased corpora lutea number	J:51663
	decreased litter size	J:51663
	decreased neuron number	J:67862
	decreased superovulation rate	J:51663
	enlarged liver	J:83617
	enlarged lymph nodes	J:83617
	enlarged spleen	J:83617
	failure of superovulation	J:51663
	impaired ovarian folliculogenesis	J:51663
	increased aggression towards male mice	J:66582
	increased atretic ovarian follicle number	J:51663
	increased bone marrow cell number	J:83617
	increased chronic myelocytic leukemia incidence	J:83617
	increased circulating insulin-like growth factor I level	J:110416
	increased compact bone area	J:91765
	increased erythrocyte cell number	J:83617
	increased granulocyte number	J:83617
	increased keratinocyte apoptosis	J:107589
	increased leukocyte cell number	J:83617
	increased megakaryocyte cell number	J:83617
	increased monocyte cell number	J:83617
	increased neutrophil cell number	J:83617
	increased osteoblast cell number	J:91765
	increased pre-B cell number	J:83617
	increased pro-B cell number	J:83617
	increased systemic arterial blood pressure	J:73898
	increased vasoconstriction	J:73898
	myelofibrosis	J:83617
	neuron degeneration	J:67862
	prostate gland epithelial hyperplasia	J:51663
	reduced female fertility	J:51663
	normal reproductive system phenotype	J:51663
	normal skeleton phenotype	J:62222
	spleen hyperplasia	J:83617
	spleen hypoplasia	J:110416
	thin epidermis	J:107589