95 phenotypes from 16 alleles in 26 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Brca2tm1.1Brn/Brca2tm1.1Brn involves: 129P2/OlaHsd * BALB/cJ * FVB/N	abnormal embryo development	J:73028
	embryonic growth retardation	J:73028
	embryonic lethality, complete penetrance	J:73028
Brca2tm1.1Sks/Brca2tm1.1Sks involves: 129 * C57BL/6J * FVB/N	normal reproductive system phenotype	J:187434
Brca2tm1Arge/Brca2+ involves: 129S/SvEv * C57BL/6	normal neoplasm	J:40594
Brca2tm1Arge/Brca2tm1Arge involves: 129S/SvEv * C57BL/6	abnormal amnion morphology	J:40594
	abnormal embryo development	J:40594
	abnormal extraembryonic tissue morphology	J:40594
	abnormal proamniotic cavity morphology	J:40594
	abnormal visceral yolk sac morphology	J:40594
	decreased embryo size	J:40594
	embryonic lethality, complete penetrance	J:40594
	enlarged allantois	J:40594
Brca2tm1Arge/Brca2tm2Arge involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:70564
Brca2tm1Arge/Brca2tm2Arge Waptm1(cre)Arge/Wap+ involves: 129S/SvEv * C57BL/6	increased mammary adenocarcinoma incidence	J:70564
Brca2tm1Brd/Brca2+ involves: 129S7/SvEvBrd	no abnormal phenotype detected	J:39764
Brca2tm1Brd/Brca2tm1.1Sks involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N	normal reproductive system phenotype	J:187434
Brca2tm1Brd/Brca2tm1Brd involves: 129S7/SvEvBrd	abnormal developmental patterning	J:39764
	abnormal embryonic tissue morphology	J:39764
	abnormal extraembryonic tissue morphology	J:39764
	prenatal lethality, complete penetrance	J:39764
Brca2tm1Brn/Brca2tm1Brn involves: 129P2/OlaHsd * FVB/N	no abnormal phenotype detected	J:73028
Brca2tm1Brn/Brca2tm1Brn Cd19tm1(cre)Cgn/Cd19+ involves: 129P2/OlaHsd	chromosome breakage	J:197442
Brca2tm1Brn/Brca2tm1Brn Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	normal nervous system phenotype	J:144617
Brca2tm1Brn/Brca2tm1Brn Tg(Pbsn-cre)4Prb/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal prostate gland physiology	J:161511
	increased prostate intraepithelial neoplasia incidence	J:161511
	prostate gland hyperplasia	J:161511
Brca2tm1Cam/Brca2tm1Brn Tg(Pdx1-cre)6Tuv/0 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N	exocrine pancreatic insufficiency	J:166678
	premature death	J:166678
Brca2tm1Cam/Brca2tm1Cam 129S/SvEv-Brca2tm1Cam	abnormal axial skeleton morphology	J:46812
	embryonic growth retardation	J:46812
	neonatal lethality, incomplete penetrance	J:46812
	postnatal lethality, incomplete penetrance	J:46812
	prenatal lethality, incomplete penetrance	J:46812
Brca2tm1Cam/Brca2tm1Cam involves: 129S/SvEv	abnormal mitosis	J:93261
Brca2tm1Cam/Brca2tm1Cam involves: 129S/SvEv * MF1	abnormal axial skeleton morphology	J:46812
	absent germ cells	J:46812
	embryonic growth retardation	J:46812
	embryonic lethality during organogenesis, incomplete penetrance	J:46812
	female infertility	J:46812
	increased T cell derived lymphoma incidence	J:46812
	increased thymus weight	J:46812
	male infertility	J:46812
	neonatal lethality, incomplete penetrance	J:46812
	perinatal lethality, incomplete penetrance	J:46812
	postnatal lethality, incomplete penetrance	J:46812
	premature death	J:46812
Brca2tm1Cbl/Brca2tm1Cbl either: (involves: 129S2/SvPas * C57BL/10) or (involves: 129S2/SvPas * C57BL/6 * DBA/2)	abnormal double-strand DNA break repair	J:44386
	abnormal epidermal layer morphology	J:44386
	abnormal epidermis stratum basale morphology	J:44386
	abnormal epidermis stratum spinosum morphology	J:44386
	abnormal rib morphology	J:44386
	abnormal skin morphology	J:44386
	abnormal sternum morphology	J:44386
	absent epidermis stratum corneum	J:44386
	absent ovarian follicles	J:44386
	azoospermia	J:44386
	decreased birth weight	J:44386
	decreased body weight	J:44386
	decreased fetal weight	J:44386
	decreased fibroblast proliferation	J:44386
	fetal growth retardation	J:44386
	increased T cell derived lymphoma incidence	J:44386
	kinked tail	J:44386
	male infertility	J:44386
	ovary degeneration	J:44386
	postnatal lethality, incomplete penetrance	J:44386
	premature death	J:44386
	small ovary	J:44386
	small testis	J:44386
Brca2tm1Hst/Brca2tm1Hst involves: 129S7/SvEvBrd * C57BL/6	decreased tumor latency	J:82434
	increased carcinoma incidence	J:82434
	increased lymphoma incidence	J:82434
	premature death	J:82434
	sepsis	J:82434
Brca2tm1Hst/Brca2tm2Hst involves: 129S7/SvEvBrd * C57BL/6	chromosomal instability	J:82434
	early cellular replicative senescence	J:82434
Brca2tm1Kamc/Brca2tm1Kamc involves: 129P2/OlaHsd	small testis	J:268570
Brca2tm1Kamc/Brca2tm1Kamc involves: 129P2/OlaHsd * BALB/c	abnormal chromosome morphology	J:144998
	abnormal DNA repair	J:144998
	abnormal hematopoietic system morphology/development	J:144998
	decreased body weight	J:144998
	decreased bone marrow cell number	J:144998
	decreased common myeloid progenitor cell number	J:144998
	impaired hematopoiesis	J:144998
	increased mortality induced by ionizing radiation	J:144998
	increased sensitivity to induced cell death	J:144998
	spleen hypoplasia	J:144998
Brca2tm1Kamc/Brca2tm1Kamc involves: 129P2/OlaHsd * C57BL/6N	abnormal branching of the mammary ductal tree	J:75026
	decreased survivor rate	J:75026, J:109193
	increased tumor incidence	J:75026
	lethality throughout fetal growth and development, incomplete penetrance	J:75026
	normal neoplasm	J:109193
	normal reproductive system phenotype	J:75026
Brca2tm1Mak/Brca2tm2Mak Tg(Lck-cre)548Jxm/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal chromosome morphology	J:79697
	aneuploidy	J:79697
	normal cellular phenotype	J:79697
	normal immune system phenotype	J:79697
	increased T cell apoptosis	J:79697
	normal neoplasm	J:79697
Brca2tm1Mbn/Brca2+ B6.Cg-Brca2tm1Mbn ApcMin	adrenal gland hyperplasia	J:67445
	normal growth/size/body region phenotype	J:67445
	increased mammary gland tumor incidence	J:67445
	normal reproductive system phenotype	J:67445
Brca2tm1Mbn/Brca2+ involves: 129P2/OlaHsd * 129S/SvEv	abnormal motor capabilities/coordination/movement	J:74077
Brca2tm1Mbn/Brca2tm1Mbn C.129P2-Brca2tm1Mbn	embryonic growth retardation	J:74077
	embryonic lethality during organogenesis, complete penetrance	J:74077
	open neural tube	J:74077
Brca2tm1Mbn/Brca2tm1Mbn involves: 129P2/OlaHsd * 129S/SvEv	embryonic lethality between somite formation and embryo turning, complete penetrance	J:74077
Brca2tm1Mhun/Brca2+ involves: 129S7/SvEvBrd * C57BL/6J	abnormal cell physiology	J:89083
	decreased incidence of tumors by chemical induction	J:89083
	decreased tumor incidence	J:89083
	increased apoptosis	J:89083
Brca2tm1Mhun/Brca2tm1Mhun involves: 129S7/SvEvBrd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:89083
Brca2tm2.1Sks/Brca2tm1Brd B6.Cg-Brca2tm1Brd Brca2tm2.1Sks	abnormal branching of the mammary ductal tree	J:323630
	normal behavior/neurological phenotype	J:323630
	decreased birth body size	J:323630
	decreased birth weight	J:323630
	decreased body size	J:323630
	decreased body weight	J:323630
	decreased embryo size	J:323630
	decreased mammary duct terminal end bud number	J:323630
	normal embryo phenotype	J:323630
	normal growth/size/body region phenotype	J:323630
	increased mortality induced by ionizing radiation	J:323630
	normal neoplasm	J:323630
	premature death	J:323630
	prenatal lethality, incomplete penetrance	J:323630
	normal reproductive system phenotype	J:323630
Brca2tm2.1Sks/Brca2tm2.1Sks Not Specified	decreased embryo size	J:323630
	normal embryo phenotype	J:323630
	normal homeostasis/metabolism phenotype	J:323630
	normal mortality/aging	J:323630
	normal neoplasm	J:323630
	prenatal lethality, incomplete penetrance	J:323630
	normal reproductive system phenotype	J:323630
Brca2tm2Arge/Brca2tm2Arge Waptm1(cre)Arge/Waptm1(cre)Arge involves: 129S1/Sv * C57BL/6	increased mammary adenocarcinoma incidence	J:70564
Brca2tm2Hst/Brca2tm2Hst involves: 129S7/SvEvBrd * C57BL/6	embryonic lethality, complete penetrance	J:82434
Brca2tm2Mak/Brca2tm2Mak involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:79697