62 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sptlc2em1(IMPC)Bay/Sptlc2em1(IMPC)Bay C57BL/6N-Sptlc2em1(IMPC)Bay/Bay	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Sptlc2tm1Jia/Sptlc2+ B6.Cg-Sptlc2tm1Jia	abnormal circulating lipid level	J:140627
	abnormal lipid level	J:140627
Sptlc2tm1Jia/Sptlc2tm1Jia B6.Cg-Sptlc2tm1Jia	prenatal lethality, complete penetrance	J:140627
Sptlc2tm1Yhir/Sptlc2tm1Yhir Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ involves: C57BL/6 * C57BL/6NTac	abnormal circulating protein level	J:202954
	abnormal intestinal mucosa morphology	J:202954
	abnormal large intestine crypts of Lieberkuhn morphology	J:202954
	abnormal pancreatic acinar cell zymogen granule morphology	J:202954
	abnormal small intestinal villus morphology	J:202954
	abnormal small intestine crypts of Lieberkuhn morphology	J:202954
	abnormal spleen morphology	J:202954
	abnormal stomach mucosa morphology	J:202954
	abnormal thymus morphology	J:202954
	cellular necrosis	J:202954
	decreased bone marrow cell number	J:202954
	decreased lymphocyte cell number	J:202954
	decreased spleen weight	J:202954
	decreased thymus weight	J:202954
	increased adrenal gland weight	J:202954
	increased blood urea nitrogen level	J:202954
	increased circulating alanine transaminase level	J:202954
	increased circulating serum albumin level	J:202954
	increased erythrocyte cell number	J:202954
	increased hematocrit	J:202954
	increased hemoglobin content	J:202954
	increased neutrophil cell number	J:202954
	reticulocytopenia	J:202954
	sebaceous gland atrophy	J:202954
Sptlc2tm1Yhir/Sptlc2tm1Yhir Tg(KRT5-cre)1Tak/0 involves: C3H * C57BL/6	abnormal ceramide level	J:202388
	abnormal dendritic epidermal T cell morphology	J:202388
	abnormal epidermal lamellar body morphology	J:202388
	abnormal epidermis stratum corneum morphology	J:202388
	abnormal epidermis stratum granulosum morphology	J:202388
	abnormal Langerhans cell morphology	J:202388
	abnormal Langerhans cell physiology	J:202388
	absent epidermis stratum granulosum	J:202388
	acanthosis	J:202388
	alopecia	J:202388
	dehydration	J:202388
	delayed skin barrier formation	J:202388
	dry skin	J:202388
	epidermal hyperplasia	J:202388
	hyperkeratosis	J:202388
	impaired skin barrier function	J:202388
	increased dendritic cell number	J:202388
	increased gamma-delta T cell number	J:202388
	increased T-helper 17 cell number	J:202388
	postnatal growth retardation	J:202388
	premature death	J:202388
	psoriasis	J:202388
	reddish skin	J:202388
	scaly skin	J:202388
	skin inflammation	J:202388
	skin lesions	J:202388
	sparse hair	J:202388
Sptlc2tm2.1Jia/Sptlc2tm2.1Jia involves: 129S4/SvJaeSor * C57BL/6	abnormal liver physiology	J:155507
	abnormal sphingomyelin level	J:155507
	increased cholesterol efflux	J:155507
	increased circulating cholesterol level	J:155507
	increased circulating HDL cholesterol level	J:155507
	increased circulating phospholipid level	J:155507