Sptlc2tm2.1Jia
Targeted Allele Detail
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Symbol: |
Sptlc2tm2.1Jia |
Name: |
serine palmitoyltransferase, long chain base subunit 2; targeted mutation 2.1, Xian-cheng Jiang |
MGI ID: |
MGI:4414752 |
Synonyms: |
Sptlc2Flox |
Gene: |
Sptlc2 Location: Chr12:87351832-87435129 bp, - strand Genetic Position: Chr12, 41.52 cM, cytoband E
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Alliance: |
Sptlc2tm2.1Jia page
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Germline Transmission: |
Earliest citation of germline transmission:
J:155507
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed.
(J:155507)
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Generation of Sptlc2tm2.1Jia allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sptlc2 Mutation: |
170 strains or lines available
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Original: |
J:155507 Li Z, et al., Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels. J Biol Chem. 2009 Sep 25;284(39):27010-9 |
All: |
6 reference(s) |
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