44 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+ Edil3Tg(Sox2-cre)1Amc/Edil3+ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA	no abnormal phenotype detected	J:194078
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex involves: 129S5/SvEvBrd	abnormal cell cycle	J:77907
	abnormal nervous system development	J:77907
	abnormal neural tube closure	J:77907
	decreased cell proliferation	J:77907
	decreased embryo size	J:77907
	dilated lateral ventricle	J:77907
	embryonic lethality during organogenesis, complete penetrance	J:77907
	pallor	J:77907
	telencephalon hypoplasia	J:77907
Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal embryo development	J:166152
	decreased cell proliferation	J:166152
	embryonic lethality during organogenesis, incomplete penetrance	J:166152
Mdm4m1Btlr/Mdm4m1Btlr C57BL/6J-Mdm4m1Btlr	decreased CD8-positive, alpha-beta T cell number	J:265262
	decreased single-positive T cell number	J:265262
	increased CD4-positive, alpha-beta T cell number	J:265262
	increased single-positive T cell number	J:265262
Mdm4m2Btlr/Mdm4m2Btlr C57BL/6J-Mdm4m2Btlr	decreased CD8-positive, alpha-beta T cell number	J:272830
	increased CD4-positive, alpha-beta T cell number	J:272830
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl involves: 129S/Sv * C57BL/6	decreased cellular sensitivity to gamma-irradiation	J:150341
	decreased mortality induced by ionizing radiation	J:150341
	decreased thymocyte apoptosis	J:150341
	increased erythrocyte cell number	J:150341
	increased leukocyte cell number	J:150341
	normal neoplasm	J:150341
	thrombocytosis	J:150341
Mdm4tm1Glo/Mdm4+ involves: 129S6/SvEvTac * C57BL/6	abnormal cell physiology	J:123661
	increased mortality induced by ionizing radiation	J:123661
Mdm4tm1Glo/Mdm4+ Not Specified	increased foot pad pigmentation	J:174216
	increased mortality induced by ionizing radiation	J:174368
Mdm4tm1Glo/Mdm4tm1Glo Not Specified	decreased cell proliferation	J:71532
	embryonic lethality between implantation and somite formation, complete penetrance	J:71532
Mdm4tm1Zmy/Mdm4tm1Zmy involves: 129 * C57BL/6	abnormal embryonic neuroepithelium morphology	J:174359
	abnormal heart development	J:174359
	absent somites	J:174359
	decreased cell proliferation	J:174359
	decreased embryo size	J:174359
	embryonic lethality during organogenesis, complete penetrance	J:174359
	increased embryonic tissue cell apoptosis	J:174359
Mdm4tm2.1Glo/Mdm4tm2.1Glo involves: 129S4/SvJaeSor * C57BL/6J	prenatal lethality, complete penetrance	J:104114
Mdm4tm2Glo/Mdm4tm2.1Glo Tg(Myh6-cre)2182Mds/0 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N	cardiac fibrosis	J:137114
	normal cardiovascular system phenotype	J:104114
	congestive heart failure	J:137114
	decreased myocardial fiber number	J:137114
	dilated cardiomyopathy	J:137114
	dilated heart ventricle	J:137114
	edema	J:137114
	enlarged heart	J:137114
	increased cardiomyocyte apoptosis	J:137114
	increased myocardial fiber size	J:137114
	premature death	J:104114, J:137114
	thin ventricular wall	J:137114