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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Npm1
nucleophosmin 1
MGI:106184
63 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow
abnormal bone marrow cell physiology J:272803
abnormal bone marrow hematopoietic cell morphology J:272803
decreased hematopoietic stem cell number J:272803
increased granulocyte monocyte progenitor cell number J:272803
Npm1Gt(OST331547)Lex/Npm1+
B6;129S5-Npm1Gt(OST331547)Lex/Mmucd
abnormal hematopoietic stem cell physiology J:188985
normal hematopoietic system phenotype J:188985
increased hematopoietic stem cell number J:188985
Npm1Gt(OST331547)Lex/Npm1Gt(OST331547)Lex
B6;129S5-Npm1Gt(OST331547)Lex/Mmucd
embryonic lethality, complete penetrance J:188985
Npm1Gt(OST331547)Lex/Npm1Gt(OST331547)Lex
involves: 129S5/SvEvBrd * C57BL/6J
neonatal lethality, complete penetrance J:103485
Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
involves: 129S5/SvEvBrd * C57BL/6
abnormal cell proliferation J:101353
abnormal placenta development J:101353
decreased embryo size J:101353
normal embryo phenotype J:101353
embryonic growth arrest J:101353
embryonic lethality during organogenesis, complete penetrance J:101353
increased apoptosis J:101353
increased fibroblast apoptosis J:101353
Npm1tm1Gsva/Npm1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA
abnormal common myeloid progenitor cell morphology J:172071
decreased B cell number J:172071
enlarged liver J:172071
enlarged spleen J:172071
increased acute promyelocytic leukemia incidence J:172071
increased B cell derived lymphoma incidence J:172071
increased granulocyte number J:172071
increased leukocyte cell number J:172071
increased liver weight J:172071
increased mean corpuscular volume J:172071
increased mean platelet volume J:172071
increased spleen weight J:172071
premature death J:172071
Npm1tm1Gsva/Npm1tm1Gsva
Dppa3tm1(cre)Peli/Dppa3+
involves: 129S5/SvEvBrd * 129S7/SvEvBrd
embryonic lethality, complete penetrance J:172071
Npm1tm1Hft/Npm1+
involves: 129
abnormal bone marrow cell morphology/development J:194999
abnormal common myeloid progenitor cell morphology J:194999
abnormal granulocyte differentiation J:194999
abnormal spleen B cell follicle morphology J:194999
enlarged spleen J:194999
extramedullary hematopoiesis J:194999
normal hematopoietic system phenotype J:194999
increased granulocyte number J:194999
increased hematopoietic stem cell number J:194999
increased leukocyte cell number J:194999
increased monocyte cell number J:194999
increased spleen weight J:194999
myeloid hyperplasia J:194999
normal neoplasm J:194999
thrombocytosis J:194999
Npm1tm1Hft/Npm1tm1Hft
involves: 129
embryonic lethality, complete penetrance J:194999
Npm1tm1Ppp/Npm1+
involves: 129S1/Sv * C57BL/6
abnormal cell proliferation J:101494
abnormal megakaryocyte morphology J:101494
abnormal proerythroblast morphology J:101494
abnormal thrombopoiesis J:101494
anisocytosis J:101494
chromosome breakage J:101494
increased bone marrow cell number J:101494
increased mean corpuscular volume J:101494
lethality throughout fetal growth and development, incomplete penetrance J:101494
reticulocytopenia J:101494
Npm1tm1Ppp/Npm1tm1Ppp
involves: 129S1/Sv * C57BL/6
abnormal brain morphology J:101494
abnormal cell cycle J:101494
abnormal embryonic hematopoiesis J:101494
abnormal visceral yolk sac blood island morphology J:101494
absent forebrain J:101494
absent liver J:101494
absent vitelline blood vessels J:101494
anemia J:101494
anophthalmia J:101494
decreased embryo size J:101494
decreased fibroblast proliferation J:101494
embryonic lethality during organogenesis, complete penetrance J:101494
increased embryonic tissue cell apoptosis J:101494
pallor J:101494
small placenta J:101494
Npm1tm2Ppp/Npm1tm2Ppp
involves: 129S1/Sv * C57BL/6
abnormal embryonic hematopoiesis J:101494
abnormal eye development J:101494
abnormal forebrain development J:101494
abnormal vitelline vasculature morphology J:101494
anemia J:101494
chromosome breakage J:101494
decreased embryo size J:101494
decreased fibroblast proliferation J:101494
lethality throughout fetal growth and development, complete penetrance J:101494
pallor J:101494

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory