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Atg5 Gene Detail
Summary
  • Symbol
    Atg5
  • Name
    autophagy related 5
  • Synonyms
    2010107M05Rik, 3110067M24Rik, Apg5l, Paddy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277186
    NCBI Gene: 11793
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:44144354-44240287 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277186
 protein coding gene Chr10:44144325-44240295 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017204
 protein coding gene Chr10:43111268-43217067 (+)
A/J MGP_AJ_G0017180
 protein coding gene Chr10:41891692-41992976 (+)
AKR/J MGP_AKRJ_G0017139
 protein coding gene Chr10:42564251-42660728 (+)
BALB/cJ MGP_BALBcJ_G0017141
 protein coding gene Chr10:41955780-42051242 (+)
C3H/HeJ MGP_C3HHeJ_G0016965
 protein coding gene Chr10:42874858-42972753 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017599
 protein coding gene Chr10:44422475-44527605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015294
 protein coding gene Chr10:39816214-39910389 (+)
CAST/EiJ MGP_CASTEiJ_G0016539
 protein coding gene Chr10:43118017-43222694 (+)
CBA/J MGP_CBAJ_G0016936
 protein coding gene Chr10:46425526-46540011 (+)
DBA/2J MGP_DBA2J_G0017041
 protein coding gene Chr10:41331125-41428231 (+)
FVB/NJ MGP_FVBNJ_G0017035
 protein coding gene Chr10:40841915-40936689 (+)
LP/J MGP_LPJ_G0017116
 protein coding gene Chr10:43133575-43245253 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017064
 protein coding gene Chr10:47123013-47224865 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017635
 protein coding gene Chr10:42557182-42664597 (+)
PWK/PhJ MGP_PWKPhJ_G0016318
 protein coding gene Chr10:41281341-41385449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016103
 protein coding gene Chr10:42387521-42484544 (+)
WSB/EiJ MGP_WSBEiJ_G0016602
 protein coding gene Chr10:42811324-42909887 (+)



Homology
more
  • Human Ortholog
    ATG5, autophagy related 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG5, autophagy related 5
  • Synonyms
    APG5, APG5L, APG5-LIKE, ASP, hAPG5, SCAR25
  • Links
    NCBI Gene ID: 9474
    neXtProt AC: NX_Q9H1Y0
    UniProt: Q9H1Y0

  • Chr Location
    6q21; chr6:106045423-106325791 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atg5 mouse models; 1 with human ATG5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    126 phenotypes from 4 alleles in 20 genetic backgrounds
    13 phenotypes from multigenic genotypes
    4 images
    359 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene results in impaired autophagy due to absence of autolysosomes. Homozygotes die within 1 day of birth, and have shorter survival times and reduced amino acid levels under fasting conditions. Homozygotes for a gene trap insertion mutationin this gene show no abnormal phenotype. A kidney proximal tubular cell-specific KO allele exacerbates renal inflammation in mice subjected to unilateral ureteric obstruction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    55
  • cDNA Data
    80
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038160 Ensembl Gene Model | MGI Sequence Detail 95934 C57BL/6J ±  kb
    transcript ENSMUST00000039286 Ensembl | MGI Sequence Detail 2352 Not Applicable  
    polypeptide ENSMUSP00000044769 Ensembl | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 81
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1277148, MGI:1917267, MGI:1920439, MGI:2143833, MGI:2143950
    References
    more
    • Summaries
      All 501
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 34
      Phenotypes 359
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346061 Liu Y, et al., Autophagy regulates the maturation of hematopoietic precursors in the embryo. Nat Commun. 2024 Mar 15;15(1):2255
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory