GO Annotations Graph

• Symbol: Npm1
• Name: nucleophosmin 1
• ID: MGI:106184

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:207374
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0002039	p53 binding	ISO	J:155856
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:161028
Molecular Function	GO:0005515	protein binding	IPI	J:196116
Molecular Function	GO:0005515	protein binding	IPI	J:109067
Molecular Function	GO:0005515	protein binding	IPI	J:96946
Molecular Function	GO:0005515	protein binding	IPI	J:138546
Molecular Function	GO:0005515	protein binding	IPI	J:96946
Molecular Function	GO:0005515	protein binding	IPI	J:207374
Molecular Function	GO:0005515	protein binding	IPI	J:48490
Molecular Function	GO:0005515	protein binding	IPI	J:157813
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0005515	protein binding	IPI	J:96946
Molecular Function	GO:0005515	protein binding	IPI	J:96946
Molecular Function	GO:0005515	protein binding	IPI	J:96946
Molecular Function	GO:0005515	protein binding	IPI	J:207374
Molecular Function	GO:0005515	protein binding	IPI	J:117631
Molecular Function	GO:0005515	protein binding	IPI	J:117631
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043422	protein kinase B binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0043023	ribosomal large subunit binding	ISO	J:142821
Molecular Function	GO:0043024	ribosomal small subunit binding	ISO	J:142821
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	IDA	J:105455
Molecular Function	GO:0019843	rRNA binding	ISO	J:164563
Molecular Function	GO:0019843	rRNA binding	IDA	J:142821
Molecular Function	GO:0019843	rRNA binding	IDA	J:96946
Molecular Function	GO:0030957	Tat protein binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0005813	centrosome	IDA	J:103773
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:109067
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:142821
Cellular Component	GO:0001652	granular component	IDA	J:94174
Cellular Component	GO:0015934	large ribosomal subunit	IDA	J:142821
Cellular Component	GO:0016363	nuclear matrix	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	IDA	J:105455
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	IBA	J:265628
Cellular Component	GO:0005730	nucleolus	IDA	J:64959
Cellular Component	GO:0005730	nucleolus	IDA	J:130226
Cellular Component	GO:0005730	nucleolus	IDA	J:103773
Cellular Component	GO:0005730	nucleolus	IDA	J:100984
Cellular Component	GO:0005730	nucleolus	ISO	J:69659
Cellular Component	GO:0005730	nucleolus	IDA	J:94965
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005730	nucleolus	IDA	J:99711
Cellular Component	GO:0005730	nucleolus	IDA	J:114487
Cellular Component	GO:0005730	nucleolus	IDA	J:96946
Cellular Component	GO:0005730	nucleolus	ISO	J:117454
Cellular Component	GO:0005730	nucleolus	IDA	J:138546
Cellular Component	GO:0005730	nucleolus	IDA	J:32712
Cellular Component	GO:0005730	nucleolus	IDA	J:32712
Cellular Component	GO:0005730	nucleolus	IDA	J:103132
Cellular Component	GO:0005730	nucleolus	IDA	J:94174
Cellular Component	GO:0005730	nucleolus	IDA	J:80713
Cellular Component	GO:0005730	nucleolus	IDA	J:32712
Cellular Component	GO:0005730	nucleolus	IDA	J:109067
Cellular Component	GO:0005730	nucleolus	IDA	J:142821
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	IDA	J:80713
Cellular Component	GO:0005654	nucleoplasm	IDA	J:142821
Cellular Component	GO:0005654	nucleoplasm	IDA	J:103773
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:109067
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:1990904	ribonucleoprotein complex	IBA	J:265628
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:142821
Cellular Component	GO:0015935	small ribosomal subunit	IDA	J:142821
Cellular Component	GO:0031616	spindle pole centrosome	ISO	J:164563
Biological Process	GO:0006884	cell volume homeostasis	IMP	J:142821
Biological Process	GO:0006884	cell volume homeostasis	IDA	J:142821
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0007098	centrosome cycle	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	IBA	J:265628
Biological Process	GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO	J:155856
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:138546
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010826	negative regulation of centrosome duplication	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:138546
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	IDA	J:105455
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0006913	nucleocytoplasmic transport	ISO	J:164563
Biological Process	GO:0006913	nucleocytoplasmic transport	IDA	J:94174
Biological Process	GO:0006334	nucleosome assembly	ISO	J:164563
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:155856
Biological Process	GO:1902751	positive regulation of cell cycle G2/M phase transition	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:142821
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:142821
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process	IMP	J:142821
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process	IDA	J:142821
Biological Process	GO:0010825	positive regulation of centrosome duplication	IGI	J:117631
Biological Process	GO:0051054	positive regulation of DNA metabolic process	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:117631
Biological Process	GO:1904751	positive regulation of protein localization to nucleolus	IMP	J:138546
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:138546
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:240385
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	IMP	J:138546
Biological Process	GO:0031648	protein destabilization	IMP	MGI:MGI:62033
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0008104	protein localization	IMP	J:101353
Biological Process	GO:0050821	protein stabilization	IMP	J:240385
Biological Process	GO:0050821	protein stabilization	IMP	J:138546
Biological Process	GO:0050821	protein stabilization	IGI	J:138546
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:94174
Biological Process	GO:0001558	regulation of cell growth	IDA	J:142821
Biological Process	GO:0046599	regulation of centriole replication	ISO	J:164563
Biological Process	GO:0010824	regulation of centrosome duplication	IBA	J:265628
Biological Process	GO:0010824	regulation of centrosome duplication	IMP	J:101494
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	IGI	J:101353
Biological Process	GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	ISO	J:164563
Biological Process	GO:0032071	regulation of endodeoxyribonuclease activity	ISO	J:164563
Biological Process	GO:0060699	regulation of endoribonuclease activity	ISO	J:164563
Biological Process	GO:1902629	regulation of mRNA stability involved in cellular response to UV	ISO	J:164563
Biological Process	GO:0043523	regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0031647	regulation of protein stability	IMP	J:138546
Biological Process	GO:0042273	ribosomal large subunit biogenesis	IBA	J:265628
Biological Process	GO:0042273	ribosomal large subunit biogenesis	IMP	J:142821
Biological Process	GO:0042273	ribosomal large subunit biogenesis	IDA	J:142821
Biological Process	GO:0000055	ribosomal large subunit export from nucleus	IBA	J:265628
Biological Process	GO:0000055	ribosomal large subunit export from nucleus	IMP	J:142821
Biological Process	GO:0042274	ribosomal small subunit biogenesis	IBA	J:265628
Biological Process	GO:0042274	ribosomal small subunit biogenesis	IDA	J:142821
Biological Process	GO:0042274	ribosomal small subunit biogenesis	IMP	J:142821
Biological Process	GO:0000056	ribosomal small subunit export from nucleus	IBA	J:265628
Biological Process	GO:0000056	ribosomal small subunit export from nucleus	IDA	J:142821
Biological Process	GO:0006407	rRNA export from nucleus	IBA	J:265628
Biological Process	GO:0006407	rRNA export from nucleus	IDA	J:142821
Biological Process	GO:0006407	rRNA export from nucleus	IMP	J:142821
Biological Process	GO:0009303	rRNA transcription	ISO	J:155856