Human Disease | Mouse Models | ||||
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early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
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Transcription Start Site | Location | Distance from Gene 5'-end |
Tssr62566 | Chr6:116438112-116438133 (-) | 16 bp |
Tssr62565 | Chr6:116438081-116438101 (-) | 48 bp |
Tssr1975 | Chr6:116435826-116435863 (-) | 2,294 bp |
Tssr62564 | Chr6:116400947-116400948 (-) | 37,191 bp |
Tssr62563 | Chr6:116391005-116391014 (-) | 47,129 bp |
QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
Bdt3 | Chr6, 63.63 cM | J:104825 | Previously identified QTL Bdt3 (bone density traits 3) at 67 cM on mouse Chromosome 6 is a pleiotropic locus associated with obesity, leptin levels, bone density, and VLDL/LDL levels. (C57BL/6J x DBA/2J)F2 animals homozygous for DBA/2J-derived alleles atBdt3 exhibit increased fat pad mass, plasma leptin, bone mineral density, and plasma VLDL/LDL cholesterol compared to F2 animals homozygous for C57BL/6J-derived alleles. F2 animals homozygous for DBA/2J-derived alleles at Alox5 (53.2 cM) also follow the same phenotypic pattern. In addition, B6.129S2-Alox5 |
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Igf1sl1 | Chr6, 53.75 cM | Chr6:52138693-116132228 | J:99471 | Igf1sl1 is a QTL previously identified in a congenic line named B6.C3-(D6Mit93-D6Mit150). Authors refer to this line as 6T. The congenic carries a C3H/HeJ-derived interval between D6Mit93 (26.3 cM) to D6Mit150 (51 cM) on a C57BL/6J genetic background. The congenic exhibits 30%-50% decreased IGF-1 expression in bone, liver, and fat tissue, and a 20% decrease in serum IGF-1 levels compared to background strain C57BL/6J. IGFBP-2 expression also appears to be decreased in bone. The congenic also exhibits decreased rate of bone formation and significantly increased percent body fat compared to C57BL/6J. B6.C3-(D6Mit93-D6Mit150) did not respond well to parathyroid hormone (PTH) treatment as bone mineral density did not increased significantly after 4 week of daily injections with PTH. Alox5 (53.2 cM) is a potential candidate gene mapping near Igf1sl1. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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