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Oprm1 Gene Detail
Summary
  • Symbol
    Oprm1
  • Name
    opioid receptor, mu 1
  • Synonyms
    MOP-R, MOP receptor, mor, MOR-1, muOR, Oprm
  • Feature Type
    protein coding gene
  • IDs
    MGI:97441
    NCBI Gene: 18390
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:6708593-6988209 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 1.85 cM, cytoband A2
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2076 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97441
 protein coding gene Chr10:6708506-6988209 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016990
 protein coding gene Chr10:3882082-4192774 (+)
A/J MGP_AJ_G0016968
 protein coding gene Chr10:3694066-4002961 (+)
AKR/J MGP_AKRJ_G0016933
 protein coding gene Chr10:3747357-4061933 (+)
BALB/cJ MGP_BALBcJ_G0016926
 protein coding gene Chr10:3664157-3942334 (+)
C3H/HeJ MGP_C3HHeJ_G0016751
 protein coding gene Chr10:3902022-4199764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017389
 protein coding gene Chr10:4028143-4331684 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015094
 protein coding gene Chr10:3359580-3624501 (+)
CAST/EiJ MGP_CASTEiJ_G0016333
 protein coding gene Chr10:3866425-4163692 (+)
CBA/J MGP_CBAJ_G0016723
 protein coding gene Chr10:4173626-4490837 (+)
DBA/2J MGP_DBA2J_G0016831
 protein coding gene Chr10:3667118-3943657 (+)
FVB/NJ MGP_FVBNJ_G0016826
 protein coding gene Chr10:3581917-3859363 (+)
LP/J MGP_LPJ_G0016906
 protein coding gene Chr10:3770965-4056802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016856
 protein coding gene Chr10:4029537-4355218 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017426
 protein coding gene Chr10:3748084-4030889 (+)
PWK/PhJ MGP_PWKPhJ_G0016119
 protein coding gene Chr10:3644321-3922883 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015900
 protein coding gene Chr10:3939981-4232625 (+)
WSB/EiJ MGP_WSBEiJ_G0016395
 protein coding gene Chr10:3809370-4110696 (+)



Homology
more
  • Human Ortholog
    OPRM1, opioid receptor mu 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPRM1, opioid receptor mu 1
  • Synonyms
    LMOR, MOP, MOR, MOR1, M-OR-1, OPRM
  • Links
    NCBI Gene ID: 4988
    neXtProt AC: NX_P35372
    UniProt: P35372

  • Chr Location
    6q25.2; chr6:154010496-154246867 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Oprm1 mouse models; 10 with human OPRM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 16 alleles in 21 genetic backgrounds
    9 phenotypes from multigenic genotypes
    220 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    946
  • Tissues
    128
  • cDNA Data
    14
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18390 NCBI Gene Model | MGI Sequence Detail 279617 C57BL/6J ±  kb
    transcript NM_001304955 RefSeq | MGI Sequence Detail 2778 ZRU/MplStud  
    polypeptide P42866 UniProt | EBI | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 8
      cDNA 16
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13041
    References
    more
    • Summaries
      All 360
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 16
      Phenotypes 220
    • Earliest
      J:322698 Inturrisi CE, et al., Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4
    • Latest
      J:347012 Sayar-Atasoy N, et al., Opioidergic signaling contributes to food-mediated suppression of AgRP neurons. Cell Rep. 2024 Jan 1;43(1):113630
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory