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Slc1a3
Gene Detail
Symbol

Name
ID
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
MGI:99917
Synonyms
B430115D02Rik, Eaat1, GLAST, Gmt1, MGluT1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.82 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:8634124-8710764 bp, - strand
From VEGA annotation of GRCm38

  76641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC1A3
Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a3

Human
homologs
SLC1A3, solute carrier family 1 (glial high affinity glutamate transporter), member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6507
neXtProt AC: NX_P43003

Human Synonyms: EA6, EAAT1, GLAST, GLAST1

Human Chr (Location): 5p13; chr5:36606355-36688334 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC1A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(39) Targeted(9) Transposon induced(1)
Genomic Mutations involving Slc1a3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display no abnormalities with respect to appearance or survival but do display functional abnormalities related to the central nervous system.
 
Human Diseases Modeled in Mice Using Slc1a3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc1a3 interacts with 263 markers (Mir1b, Mir7-1, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (109 records)
Data Summary: Results (450)    Tissues (202)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RNA in situ 409
Western blot 6
RT-PCR 14
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SLC1A3 ; Xenbase slc1a3 ; ZFIN slc1a3a, slc1a3b    NEW 
Molecular
reagents
All nucleic(37) Genomic(6) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000032639 (Evidence)
Ensembl Gene Model ENSMUSG00000005360 (Evidence)
Entrez Gene 20512 (Evidence)
DFCI TC1573171, TC1609278, TC1613605, TC1621047, TC1679313, TC1711423, TC1713450
DoTS DT.101230680, DT.101352520, DT.101738910, DT.110794584, DT.526331, DT.91315632, DT.91338536, DT.94270271
NIA Mouse Gene Index U043878
Consensus CDS Project CCDS27373.1
International Mouse Phenotyping Consortium Status Slc1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032639 VEGA Gene Model | MGI Sequence Detail 76641 C57BL/6J ±  kb
transcript OTTMUST00000081197 VEGA | MGI Sequence Detail 4163 Not Applicable 
polypeptide OTTMUSP00000043391 VEGA | MGI Sequence Detail 543 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014974 excitatory amino acid transporter 1
References
(Earliest) J:16962 Tanaka K, Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993 Sep 3;159(1-2):183-6
(Latest) J:222062 Jones KM, et al., CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus. Stem Cells. 2015 Jan;33(1):196-210
All references(218)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16014, MGD-MRK-16274, MGD-MRK-16718, MGI:2146029, MGI:2444735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory