About   Help   FAQ
Slc1a3
Gene Detail
 Symbol
Name
ID
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
MGI:99917
Synonyms B430115D02Rik, Eaat1, GLAST, Gmt1, MGluT1
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.82 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:8634124-8710764 bp, - strand
From VEGA annotation of GRCm38

  76641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a3

Human
homologs
Human Homolog SLC1A3, solute carrier family 1 (glial high affinity glutamate transporter), member 3
NCBI Gene ID 6507
neXtProt AC  NX_P43003
Human Synonyms  EA6, EAAT1, GLAST, GLAST1
Human Chr (Location)  5p13; chr5:36606355-36688334 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC1A3
Alleles
and
phenotypes
All alleles(48) : Targeted(9) Gene trapped(39)
 
Mice homozygous for disruptions in this gene display no abnormalities with respect to appearance or survival but do display functional abnormalities related to the central nervous system.
 
Human Diseases Modeled Using Mouse Slc1a3 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process auditory behavior, cell morphogenesis involved in neuron differentiation, ...
Component basolateral plasma membrane, cell projection, ...
Function amino acid binding, glutamate binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (98 records)
Data Summary: Results (439)    Tissues (162)    Images (36)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 409
RT-PCR 14
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) Genomic(6) cDNA(25) Primer pair(4) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000032639 (Evidence)
Ensembl Gene ModelENSMUSG00000005360 (Evidence)
Entrez Gene20512 (Evidence)
DFCITC1573171, TC1609278, TC1613605, TC1621047, TC1679313, TC1711423, TC1713450
DoTSDT.101230680, DT.101352520, DT.101738910, DT.110794584, DT.526331, DT.91315632, DT.91338536, DT.94270271
NIA Mouse Gene IndexU043878
Consensus CDS ProjectCCDS27373.1
International Mouse Knockout Project StatusSlc1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032639 VEGA Gene Model | MGI Sequence Detail 76641 C57BL/6J ±  kb
transcript OTTMUST00000081197 VEGA | MGI Sequence Detail 4163 Not Applicable 
polypeptide OTTMUSP00000043391 VEGA | MGI Sequence Detail 543 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014974 excitatory amino acid transporter 1
References (Earliest) J:16962 Tanaka K, Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993 Sep 3;159(1-2):183-6
(Latest) J:205567 Li K, et al., Shp2-Dependent ERK Signaling Is Essential for Induction of Bergmann Glia and Foliation of the Cerebellum. J Neurosci. 2014 Jan 15;34(3):922-31
All references(200)
Other
accession IDs
MGD-MRK-16014, MGD-MRK-16274, MGD-MRK-16718, MGI:2146029, MGI:2444735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory