Slc1a3
Gene Detail

Symbol

Name
ID

Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
MGI:99917

Synonyms

B430115D02Rik, Eaat1, GLAST, Gmt1, MGluT1

Feature Type

protein coding gene

Genetic Map

Chromosome 15
3.82 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr15:8634124-8710764 bp, - strand From VEGA annotation of GRCm38   76641 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a3

Human
homologs

Human Homolog		SLC1A3, solute carrier family 1 (glial high affinity glutamate transporter), member 3
NCBI Gene ID		6507
neXtProt AC		NX_P43003
Human Synonyms		EA6, EAAT1, GLAST, GLAST1
Human Chr (Location)		5p13; chr5:36606355-36688334 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human SLC1A3

Mutations,
alleles, and
phenotypes

All mutations/alleles(49) : Gene trapped(39) Targeted(9) Transposon induced(1)
Genomic Mutations involving Slc1a3 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display no abnormalities with respect to appearance or survival but do display functional abnormalities related to the central nervous system.

 
Human Diseases Modeled in Mice Using Slc1a3 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Slc1a3 interacts with 263 markers (Mir1b, Mir7-1, Mir17, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (56 annotations)

Process	auditory behavior, cell morphogenesis involved in neuron differentiation, ...
Component	basolateral plasma membrane, cell periphery, ...
Function	amino acid binding, glutamate binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (103 records)

Data Summary: Results (439)    Tissues (202)    Images (36)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	16
RNA in situ	409
RT-PCR	14

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(36) Genomic(6) cDNA(25) Primer pair(4) Other(1)
Microarray probesets(9)

Other database
links

VEGA Gene Model	OTTMUSG00000032639 (Evidence)
Ensembl Gene Model	ENSMUSG00000005360 (Evidence)
Entrez Gene	20512 (Evidence)
DFCI	TC1573171, TC1609278, TC1613605, TC1621047, TC1679313, TC1711423, TC1713450
DoTS	DT.101230680, DT.101352520, DT.101738910, DT.110794584, DT.526331, DT.91315632, DT.91338536, DT.94270271
NIA Mouse Gene Index	U043878
Consensus CDS Project	CCDS27373.1
International Mouse Knockout Project Status	Slc1a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032639	VEGA Gene Model | MGI Sequence Detail	76641	C57BL/6J
transcript	OTTMUST00000081197	VEGA | MGI Sequence Detail	4163	Not Applicable
polypeptide	OTTMUSP00000043391	VEGA | MGI Sequence Detail	543	Not Applicable

All sequences(83) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(1) : SNPs within 2kb(291 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001991	Sodium:dicarboxylate symporter
InterPro	IPR018107	Sodium:dicarboxylate symporter, conserved site
Protein Ontology	PR:000014974	excitatory amino acid transporter 1

References

(Earliest) J:16962 Tanaka K, Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993 Sep 3;159(1-2):183-6
(Latest) J:216312 Mesman S, et al., Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling. PLoS One. 2014;9(5):e97926
All references(207)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-16014, MGD-MRK-16274, MGD-MRK-16718, MGI:2146029, MGI:2444735