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Slc1a3 Gene Detail
Summary
  • Symbol
    Slc1a3
  • Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 3
  • Synonyms
    B430115D02Rik, Eaat1, GLAST, Gmt1, MGluT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99917
    NCBI Gene: 20512
Location & Maps
more
  • Sequence Map
    Chr15:8634124-8710764 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      76641 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.82 cM, cytoband A2
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    SLC1A3, solute carrier family 1 member 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC1A3, solute carrier family 1 member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EA6, EAAT1, GLAST, GLAST1
  • Links
    NCBI Gene ID: 6507
    neXtProt AC: NX_P43003

  • Chr Location
    5p13; chr5:36606355-36688334 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Slc1a3 mouse models; 1 with human SLC1A3 associations

Human Disease Mouse Models
       Glaucoma, Normal Tension, Susceptibility to   OMIM: 606657 View 1 model
       Episodic Ataxia, Type 6; EA6   OMIM: 612656
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    49
  • Gene trapped
    39
  • Targeted
    9
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Slc1a3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruptions in this gene display no abnormalities with respect to appearance or survival but do display functional abnormalities related to the central nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    51
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    472
  • Tissues
    213
  • cDNA Data
    25
  • Literature Summary
    118
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032639 VEGA Gene Model | MGI Sequence Detail 76641 C57BL/6J ±  kb
transcript OTTMUST00000081197 VEGA | MGI Sequence Detail 4163 Not Applicable  
polypeptide OTTMUSP00000043391 VEGA | MGI Sequence Detail 543 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    291 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000014974 excitatory amino acid transporter 1
  • InterPro Domains
    IPR001991 Sodium:dicarboxylate symporter
    IPR018107 Sodium:dicarboxylate symporter, conserved site
Molecular
Reagents
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  • All nucleic 37
    Genomic 6
    cDNA 26
    Primer pair 4
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-16014, MGD-MRK-16274, MGD-MRK-16718, MGI:2146029, MGI:2444735
References
more
  • Summaries
    All 233
    Developmental Gene Expression 118
    Diseases 2
    Gene Ontology 19
    Phenotypes 71
  • Earliest
    J:16962 Tanaka K, Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993 Sep 3;159(1-2):183-6
  • Latest
    J:233820 Urban N, et al., Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science. 2016 Jul 15;353(6296):292-5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory