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Targeted Allele Detail
Symbol: Slc1a3tm1Kta
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 1, Kohichi Tanaka
MGI ID: MGI:1931872
Synonyms: GLAST-, GLAST KO
Gene: Slc1a3  Location: Chr15:8663608-8740248 bp, - strand  Genetic Position: Chr15, 3.82 cM, cytoband A2
Alliance: Slc1a3tm1Kta page
Germline Transmission:  Earliest citation of germline transmission: J:46746
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced sequences in exon 6 that code for the fourth transmembrane segment of the protein. Cerebellar transcript was not detected in homozygous mutant animals. Immunoblot analysis of cerebellar membranes did not detect protein in homozygous mutant mice. (J:46746)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc1a3 Mutation:  53 strains or lines available
Original:  J:46746 Watase K, et al., Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci. 1998 Mar;10(3):976-88
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory