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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
MGI:99917
30 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Slc1a3tm1.1(KOMP)Mbp/Slc1a3+
C57BL/6N-Slc1a3tm1.1(KOMP)Mbp/Ucd
abnormal sleep behavior J:211773
increased vertical activity J:211773
Slc1a3tm1Kta/Slc1a3tm1Kta
B6.129P2-Slc1a3tm1Kta
abnormal electroretinogram waveform feature J:124191
abnormal optic nerve morphology J:124191
abnormal retina ganglion layer morphology J:124191
abnormal retina inner nuclear layer morphology J:124191
decreased retina ganglion cell number J:124191
increased cellular sensitivity to hydrogen peroxide J:124191
increased lactate dehydrogenase level J:124191
optic nerve cupping J:124191
optic nerve degeneration J:124191
retina degeneration J:124191
normal vision/eye phenotype J:124191
Slc1a3tm1Kta/Slc1a3tm1Kta
involves: 129P2/OlaHsd
abnormal auditory brainstem response waveform shape J:66146
abnormal kindling response J:58180
abnormal motor coordination/balance J:46746
abnormal nervous system physiology J:46746
abnormal Purkinje cell morphology J:46746
abnormal synaptic glutamate release J:66146
normal behavior/neurological phenotype J:46746
cochlear inner hair cell degeneration J:99715
increased or absent threshold for auditory brainstem response J:66146
increased susceptibility to noise-induced hearing loss J:66146
increased susceptibility to ototoxicity-induced hearing loss J:99715
increased susceptibility to pharmacologically induced seizures J:58180
normal nervous system phenotype J:46746
seizures J:58180
Slc1a3tm1Wst/Slc1a3tm1Wst
involves: 129S1/Sv * 129X1/SvJ
abnormal excitatory postsynaptic currents J:93201
prolonged excitatory postsynaptic current decay time J:93201
short excitatory postsynaptic current rise time J:93201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory